登録情報 | データベース: PDB / ID: 5jel |
---|
タイトル | Phosphorylated TRIF in complex with IRF-3 |
---|
要素 | - Interferon regulatory factor 3IRF3
- Phosphorylated TRIF peptide
|
---|
キーワード | IMMUNE SYSTEM (免疫系) / Innate Immunity (自然免疫系) / Signaling |
---|
機能・相同性 | 機能・相同性情報
TICAM1 deficiency - HSE / TRAF3 deficiency - HSE / IRF3 mediated activation of type 1 IFN / MDA-5 signaling pathway / ripoptosome / MyD88-independent TLR4 cascade / macrophage apoptotic process / Toll Like Receptor 3 (TLR3) Cascade / TRIF-mediated programmed cell death / positive regulation of natural killer cell activation ...TICAM1 deficiency - HSE / TRAF3 deficiency - HSE / IRF3 mediated activation of type 1 IFN / MDA-5 signaling pathway / ripoptosome / MyD88-independent TLR4 cascade / macrophage apoptotic process / Toll Like Receptor 3 (TLR3) Cascade / TRIF-mediated programmed cell death / positive regulation of natural killer cell activation / TLR3-mediated TICAM1-dependent programmed cell death / cellular response to oxidised low-density lipoprotein particle stimulus / programmed necrotic cell death / positive regulation of myeloid dendritic cell cytokine production / Caspase activation via Death Receptors in the presence of ligand / toll-like receptor 3 signaling pathway / TRIF-dependent toll-like receptor signaling pathway / signal transduction involved in regulation of gene expression / RIP-mediated NFkB activation via ZBP1 / macrophage activation involved in immune response / IRF3-mediated induction of type I IFN / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / positive regulation of cytokine production involved in inflammatory response / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / positive regulation of macrophage cytokine production / 転写 (生物学) / toll-like receptor 4 signaling pathway / TRAF6 mediated IRF7 activation / Toll様受容体 / DNA-binding transcription activator activity / immune system process / type I interferon-mediated signaling pathway / cellular response to exogenous dsRNA / response to exogenous dsRNA / cytoplasmic pattern recognition receptor signaling pathway / B cell proliferation / antiviral innate immune response / オートファゴソーム / positive regulation of interferon-alpha production / regulation of protein-containing complex assembly / positive regulation of type I interferon production / positive regulation of autophagy / signaling adaptor activity / positive regulation of B cell proliferation / positive regulation of chemokine production / lipopolysaccharide-mediated signaling pathway / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / TICAM1,TRAF6-dependent induction of TAK1 complex / TICAM1-dependent activation of IRF3/IRF7 / nitric oxide biosynthetic process / TRAF6-mediated induction of TAK1 complex within TLR4 complex / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / TICAM1, RIP1-mediated IKK complex recruitment / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / IKK complex recruitment mediated by RIP1 / Evasion by RSV of host interferon responses / positive regulation of protein ubiquitination / Negative regulators of DDX58/IFIH1 signaling / promoter-specific chromatin binding / apoptotic signaling pathway / DDX58/IFIH1-mediated induction of interferon-alpha/beta / ISG15 antiviral mechanism / cellular response to virus / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of interleukin-6 production / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of nitric oxide biosynthetic process / positive regulation of tumor necrosis factor production / Interferon gamma signaling / Interferon alpha/beta signaling / sequence-specific double-stranded DNA binding / TRAF3-dependent IRF activation pathway / regulation of inflammatory response / DNA-binding transcription activator activity, RNA polymerase II-specific / regulation of apoptotic process / positive regulation of canonical NF-kappaB signal transduction / defense response to virus / cellular response to lipopolysaccharide / sequence-specific DNA binding / molecular adaptor activity / エンドソーム / endosome membrane / DNA-binding transcription factor activity, RNA polymerase II-specific / エンドソーム / 炎症 / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein domain specific binding / 自然免疫系 / apoptotic process / DNA damage response / クロマチン / positive regulation of gene expression / regulation of transcription by RNA polymerase II / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein homodimerization activity / positive regulation of transcription by RNA polymerase II類似検索 - 分子機能 TIR domain-containing adapter molecule 1 / TRIF, N-terminal / : / TRIF N-terminal domain / RHIM domain / RIP homotypic interaction motif / Tumour Suppressor Smad4 - #10 / Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 ...TIR domain-containing adapter molecule 1 / TRIF, N-terminal / : / TRIF N-terminal domain / RHIM domain / RIP homotypic interaction motif / Tumour Suppressor Smad4 - #10 / Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / IRF tryptophan pentad repeat DNA-binding domain signature. / Interferon regulatory factor transcription factor / interferon regulatory factor / IRF tryptophan pentad repeat DNA-binding domain profile. / Interferon regulatory factor DNA-binding domain / SMAD-like domain superfamily / Tumour Suppressor Smad4 / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / SMAD/FHA domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / サンドイッチ / Mainly Beta類似検索 - ドメイン・相同性 Interferon regulatory factor 3 / TIR domain-containing adapter molecule 1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 解像度: 1.6 Å |
---|
データ登録者 | Zhao, B. / Li, P. |
---|
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2016 タイトル: Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. 著者: Zhao, B. / Shu, C. / Gao, X. / Sankaran, B. / Du, F. / Shelton, C.L. / Herr, A.B. / Ji, J.Y. / Li, P. |
---|
履歴 | 登録 | 2016年4月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2016年6月15日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2016年6月29日 | Group: Database references |
---|
|
---|