Entry Database : PDB / ID : 5d6f Structure visualization Downloads & linksTitle Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31b ComponentsMethionine aminopeptidase 2 Methionyl aminopeptidase Details Keywords HYDROLASE / MetAP2 / methionine aminopeptidase-2 / inhibitor / spiroepoxytriazoleFunction / homology Function and homology informationFunction Domain/homology Component
N-terminal protein amino acid modification / peptidyl-methionine modification / initiator methionyl aminopeptidase activity / methionyl aminopeptidase / metalloexopeptidase activity / metalloaminopeptidase activity / aminopeptidase activity / protein processing / Inactivation, recovery and regulation of the phototransduction cascade / RNA binding ... N-terminal protein amino acid modification / peptidyl-methionine modification / initiator methionyl aminopeptidase activity / methionyl aminopeptidase / metalloexopeptidase activity / metalloaminopeptidase activity / aminopeptidase activity / protein processing / Inactivation, recovery and regulation of the phototransduction cascade / RNA binding / metal ion binding / plasma membrane / cytosol / cytoplasm Similarity search - Function Peptidase M24A, methionine aminopeptidase, subfamily 2 / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / Peptidase M24, methionine aminopeptidase / Creatine Amidinohydrolase / Creatinase/methionine aminopeptidase superfamily / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain ... Peptidase M24A, methionine aminopeptidase, subfamily 2 / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / Peptidase M24, methionine aminopeptidase / Creatine Amidinohydrolase / Creatinase/methionine aminopeptidase superfamily / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Alpha-Beta Complex / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.55 Å DetailsAuthors Janowski, R. / Miller, A.K. / Niessing, D. CitationJournal : Acs Chem.Biol. / Year : 2016Title : Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.Authors : Morgen, M. / Jost, C. / Malz, M. / Janowski, R. / Niessing, D. / Klein, C.D. / Gunkel, N. / Miller, A.K. History Deposition Aug 12, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Jan 13, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jan 27, 2016 Group : Database referencesRevision 1.2 Apr 27, 2016 Group : Database referencesRevision 1.3 Nov 20, 2019 Group : Derived calculations / Category : pdbx_struct_conn_angle / struct_connRevision 1.4 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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