登録情報 データベース : PDB / ID : 5d2m 構造の表示 ダウンロードとリンクタイトル Complex between human SUMO2-RANGAP1, UBC9 and ZNF451 要素Ran GTPase-activating protein 1 SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 2 Zinc finger protein 451 ジンクフィンガー 詳細キーワード Ligase (リガーゼ) / Protein Binding (タンパク質) / Complex / SUMO (SUMOタンパク質) / E3 Ligase (ユビキチンリガーゼ)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
: / cellular response to vasopressin / negative regulation of transcription initiation by RNA polymerase II / positive regulation of SUMO transferase activity / SUMO conjugating enzyme activity / cytoplasmic periphery of the nuclear pore complex / RING-like zinc finger domain binding / SUMO ligase activity / SUMO ligase complex / SUMOylation of nuclear envelope proteins ... : / cellular response to vasopressin / negative regulation of transcription initiation by RNA polymerase II / positive regulation of SUMO transferase activity / SUMO conjugating enzyme activity / cytoplasmic periphery of the nuclear pore complex / RING-like zinc finger domain binding / SUMO ligase activity / SUMO ligase complex / SUMOylation of nuclear envelope proteins / transferase complex / Negative regulation of activity of TFAP2 (AP-2) family transcription factors / SUMO is proteolytically processed / SUMO is conjugated to E1 (UBA2:SAE1) / SUMO is transferred from E1 to E2 (UBE2I, UBC9) / mitotic nuclear membrane reassembly / nuclear pore cytoplasmic filaments / Vitamin D (calciferol) metabolism / synaptonemal complex / small protein activating enzyme binding / SUMOylation of DNA methylation proteins / SUMOylation of immune response proteins / SUMOylation of SUMOylation proteins / Maturation of nucleoprotein / 転移酵素; アシル基を移すもの; アミノアシル基を移すもの / negative regulation of protein export from nucleus / Rev-mediated nuclear export of HIV RNA / activation of GTPase activity / SUMOylation of RNA binding proteins / 核外搬出シグナル / aggresome / SUMO transferase activity / Postmitotic nuclear pore complex (NPC) reformation / Maturation of nucleoprotein / nucleocytoplasmic transport / SUMOylation of ubiquitinylation proteins / ubiquitin-like protein ligase binding / SUMOylation of DNA replication proteins / protein sumoylation / transcription factor binding / SUMOylation of transcription factors / response to axon injury / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / SUMOylation of DNA damage response and repair proteins / 核膜孔 / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / axon cytoplasm / Resolution of Sister Chromatid Cohesion / Meiotic synapsis / SUMOylation of chromatin organization proteins / GTPase activator activity / SUMOylation of transcription cofactors / chromosome segregation / RHO GTPases Activate Formins / transcription coregulator binding / negative regulation of transforming growth factor beta receptor signaling pathway / SUMOylation of intracellular receptors / protein modification process / PKR-mediated signaling / 紡錘体 / 動原体 / PML body / small GTPase binding / Formation of Incision Complex in GG-NER / protein tag activity / Separation of Sister Chromatids / transcription corepressor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / 核膜 / Processing of DNA double-strand break ends / ubiquitin-dependent protein catabolic process / 遺伝子発現の調節 / 核膜 / positive regulation of cell migration / cadherin binding / 細胞分裂 / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / 樹状突起 / perinuclear region of cytoplasm / enzyme binding / negative regulation of transcription by RNA polymerase II / シグナル伝達 / positive regulation of transcription by RNA polymerase II / RNA binding / 核質 / ATP binding / metal ion binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 ZNF451, PIN-like domain / PIN like domain / Ran-GTPase activating protein 1, C-terminal domain / Ran-GTPase activating protein 1, C-terminal / Ran-GTPase activating protein 1, C-terminal domain superfamily / RanGAP1 C-terminal domain / : / Leucine rich repeat, ribonuclease inhibitor type / Rad60/SUMO-like domain / Ubiquitin-2 like Rad60 SUMO-like ... ZNF451, PIN-like domain / PIN like domain / Ran-GTPase activating protein 1, C-terminal domain / Ran-GTPase activating protein 1, C-terminal / Ran-GTPase activating protein 1, C-terminal domain superfamily / RanGAP1 C-terminal domain / : / Leucine rich repeat, ribonuclease inhibitor type / Rad60/SUMO-like domain / Ubiquitin-2 like Rad60 SUMO-like / ロイシンリッチリピート / Ubiquitin Conjugating Enzyme / Ubiquitin Conjugating Enzyme / Ubiquitin-conjugating enzyme, active site / Ubiquitin-conjugating (UBC) active site signature. / Ubiquitin-conjugating enzyme E2, catalytic domain homologues / Ubiquitin-conjugating enzyme E2 / ユビキチン結合酵素 / Ubiquitin-conjugating (UBC) core domain profile. / Ubiquitin-conjugating enzyme/RWD-like / ジンクフィンガー / Zinc finger C2H2 type domain profile. / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / ロイシンリッチリピート / Leucine-rich repeat domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Ubiquitin-like (UB roll) / Αソレノイド / Ubiquitin homologues / Ubiquitin domain profile. / ユビキチン様タンパク質 / Ubiquitin-like domain superfamily / Roll / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Ran GTPase-activating protein 1 / Small ubiquitin-related modifier 2 / SUMO-conjugating enzyme UBC9 / E3 SUMO-protein ligase ZNF451 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.4 Å 詳細データ登録者 Cappadocia, L. / Lima, C.D. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM065872 米国
引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2015タイトル : Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.著者 : Cappadocia, L. / Pichler, A. / Lima, C.D. 履歴 登録 2015年8月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年11月4日 Provider : repository / タイプ : Initial release改定 1.1 2015年11月18日 Group : Database references改定 1.2 2015年12月16日 Group : Database references改定 1.3 2017年9月27日 Group : Author supporting evidence / Derived calculations / カテゴリ : pdbx_audit_support / pdbx_struct_oper_listItem : _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2017年11月1日 Group : Author supporting evidence / カテゴリ : pdbx_struct_assembly_auth_evidence改定 1.5 2019年12月25日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.6 2023年9月27日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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