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- PDB-5abd: CRYSTAL STRUCTURE OF VEGFR-1 DOMAIN 2 IN PRESENCE OF CU -

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Basic information

Entry
Database: PDB / ID: 5abd
TitleCRYSTAL STRUCTURE OF VEGFR-1 DOMAIN 2 IN PRESENCE OF CU
ComponentsVASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1VEGF receptor
KeywordsSIGNALING PROTEIN / VEGF / RECEPTOR
Function / homology
Function and homology information


vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / negative regulation of vascular endothelial cell proliferation / blood vessel morphogenesis / growth factor binding ...vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / negative regulation of vascular endothelial cell proliferation / blood vessel morphogenesis / growth factor binding / monocyte chemotaxis / cellular response to vascular endothelial growth factor stimulus / vascular endothelial growth factor receptor signaling pathway / : / transmembrane receptor protein tyrosine kinase activity / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of MAP kinase activity / receptor protein-tyrosine kinase / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / cell migration / actin cytoskeleton / angiogenesis / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell differentiation / receptor complex / endosome / positive regulation of cell migration / focal adhesion / positive regulation of cell population proliferation / extracellular space / ATP binding / plasma membrane
Similarity search - Function
Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin I-set ...Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Immunoglobulin V-set domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
COPPER (II) ION / Vascular endothelial growth factor receptor 1
Similarity search - Component
Biological speciesHOMO SAPIENS (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.995 Å
AuthorsGaucher, J.-F. / Lascombe, M.-B. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. ...Gaucher, J.-F. / Lascombe, M.-B. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / Vidal, M. / Broutin, I.
CitationJournal: Plos One / Year: 2016
Title: Biophysical Studies of the Induced Dimerization of Human Vegf R Receptor 1 Binding Domain by Divalent Metals Competing with Vegf-A
Authors: Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / ...Authors: Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / Vidal, M. / Broutin, I.
History
DepositionAug 5, 2015Deposition site: PDBE / Processing site: PDBE
Revision 1.0Sep 28, 2016Provider: repository / Type: Initial release
Revision 1.1Feb 1, 2017Group: Database references
Revision 2.0Mar 6, 2019Group: Atomic model / Data collection ...Atomic model / Data collection / Experimental preparation / Other
Category: atom_site / database_PDB_rev ...atom_site / database_PDB_rev / database_PDB_rev_record / exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol
Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.pdbx_auth_atom_name / _exptl_crystal_grow.method / _exptl_crystal_grow.pdbx_details / _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval
Revision 2.1Jan 10, 2024Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
E: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
I: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
X: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)33,27612
Polymers32,7203
Non-polymers5569
Water4,035224
1
E: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)11,0263
Polymers10,9071
Non-polymers1192
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
2
I: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)11,0343
Polymers10,9071
Non-polymers1272
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
3
X: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)11,2166
Polymers10,9071
Non-polymers3105
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
Unit cell
Length a, b, c (Å)62.547, 66.189, 176.477
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number23
Space group name H-MI222
Components on special symmetry positions
IDModelComponents
11I-1225-

CU

Noncrystallographic symmetry (NCS)NCS oper:
IDCodeMatrixVector
1given(0.94145, -0.33713, 0.00417), (0.33645, 0.93863, -0.07601), (0.02171, 0.07296, 0.9971)-2.50149, 18.22159, -30.02704
2given(0.722, 0.69189, 0.00233), (0.68822, -0.7185, 0.10059), (0.07127, -0.07103, -0.99493)-9.33501, 16.45007, 116.55289

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Components

#1: Protein VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 / VEGF receptor / VEGFR-1 / FMS-LIKE TYROSINE KINASE 1 / FLT-1 / TYROSINE-PROTEIN KINASE FRT / TYROSINE-PROTEIN ...VEGFR-1 / FMS-LIKE TYROSINE KINASE 1 / FLT-1 / TYROSINE-PROTEIN KINASE FRT / TYROSINE-PROTEIN KINASE RECEPTOR FLT / FLT / VASCULAR PERMEABILITY FACTOR RECEPTOR


Mass: 10906.662 Da / Num. of mol.: 3 / Fragment: DOMAIN-2, RESIDUES 132-226
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) HOMO SAPIENS (human) / Plasmid: PET22 / Production host: ESCHERICHIA COLI (E. coli) / Strain (production host): BL21(DE3) / Variant (production host): ROSETTA-GAMI PLYSS
References: UniProt: P17948, receptor protein-tyrosine kinase
#2: Chemical ChemComp-NA / SODIUM ION


Mass: 22.990 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Na
#3: Chemical ChemComp-SO4 / SULFATE ION / Sulfate


Mass: 96.063 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: SO4
#4: Chemical
ChemComp-CU / COPPER (II) ION / Copper


Mass: 63.546 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: Cu
#5: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 224 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.91 Å3/Da / Density % sol: 57.75 % / Description: NONE
Crystal growTemperature: 291 K / Method: vapor diffusion / pH: 7.5
Details: VAPOR DIFFUSION METHOD, MOTHER LIQUOR: 1.5MICROM VERGFR1-D2, 15MM TRIS/HCL PH 8.1, 25MM NACL, 5MM CUSO4 RESERVOIR: 19.5% (W/V) PEG8000, 100MM SA,

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: ESRF / Beamline: ID23-2 / Wavelength: 0.97625
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Oct 25, 2013
RadiationMonochromator: SI(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97625 Å / Relative weight: 1
ReflectionResolution: 2→43.97 Å / Num. obs: 25367 / % possible obs: 99.8 % / Observed criterion σ(I): 0 / Redundancy: 6.3 % / Biso Wilson estimate: 35.33 Å2 / Rmerge(I) obs: 0.07 / Net I/σ(I): 15.3
Reflection shellResolution: 2→2.1 Å / Redundancy: 6 % / Rmerge(I) obs: 0.8 / Mean I/σ(I) obs: 2.1 / % possible all: 99.2

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Processing

Software
NameVersionClassification
PHENIX(PHENIX.REFINE)refinement
XDSdata reduction
SCALEPACKdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB ENTRY 4CKV

4ckv


Resolution: 1.995→43.97 Å / SU ML: 0.23 / σ(F): 1.35 / Phase error: 23.43 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2216 1292 5.1 %
Rwork0.1785 --
obs0.1809 25364 99.76 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 0.4963 Å2 / ksol: 1.0302 e/Å3
Displacement parametersBiso mean: 48.4 Å2
Refinement stepCycle: LAST / Resolution: 1.995→43.97 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms2281 0 17 224 2522
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0082365
X-RAY DIFFRACTIONf_angle_d1.113210
X-RAY DIFFRACTIONf_dihedral_angle_d14.324899
X-RAY DIFFRACTIONf_chiral_restr0.043372
X-RAY DIFFRACTIONf_plane_restr0.005400
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.9954-2.07530.32651560.28032620X-RAY DIFFRACTION99
2.0753-2.16980.2791430.25252611X-RAY DIFFRACTION100
2.1698-2.28410.23971190.22772670X-RAY DIFFRACTION100
2.2841-2.42720.27191520.21122639X-RAY DIFFRACTION100
2.4272-2.61460.23791210.21012685X-RAY DIFFRACTION100
2.6146-2.87770.25751490.19652645X-RAY DIFFRACTION100
2.8777-3.2940.2211490.18762678X-RAY DIFFRACTION100
3.294-4.14960.22391540.15562711X-RAY DIFFRACTION100
4.1496-43.98050.17111490.14242813X-RAY DIFFRACTION100
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.82543.729-2.34977.0848-0.35068.22780.22580.57240.26330.04740.18440.5311-0.9329-0.9349-0.010.37560.0437-0.02620.36710.00470.3861-31.249921.858258.2557
23.7665-1.20271.05491.87070.39822.8279-0.15440.09090.17540.11610.0661-0.1082-0.40620.1762-0.0060.3315-0.04680.00480.2874-0.00740.3251-19.440813.209557.6551
39.6958-3.02312.62744.1774-1.0074.70320.06240.16580.25650.09230.0715-0.3317-0.35670.6183-0.02160.4196-0.08580.00590.3364-0.07590.3101-17.083319.84766.3399
44.34094.1462-1.74135.5699-0.46483.52040.0979-0.04821.02240.15790.11870.6384-1.3891-0.7169-0.16580.70290.1571-0.02560.533-0.15950.5597-33.226425.172368.1483
50.8066-1.223-0.62556.44871.96592.1781-0.2732-0.848-0.40320.06340.11370.37160.1355-0.0171-0.02760.37990.01990.09610.45680.10470.3484-25.47788.522670.0346
61.85431.6236-0.78215.2130.79351.41350.1338-1.1175-0.25460.90620.1332-0.7785-0.06330.2365-0.13060.5455-0.0503-0.04160.6672-0.04860.3892-20.990517.879277.2979
77.9453-0.5045-1.19495.6059-0.29177.2271-0.1604-0.13011.30590.20410.1920.0276-1.41650.3922-0.14570.5946-0.03370.00480.3054-0.04140.4434-23.354326.454567.7439
82.2125-0.4595-0.38052.11550.95822.5044-0.2762-0.49640.08380.40930.291-0.2778-0.13440.1855-0.07690.40680.0051-0.02750.3614-0.01820.2921-20.016813.588669.7509
99.6343-0.835-1.50241.36910.13422.9824-0.1194-0.35250.2205-0.12490.00790.1502-0.0655-0.3002-0.01770.3009-0.0512-0.00840.3202-0.05250.3025-34.354614.359761.2653
105.6957-2.21932.21435.9939-1.07855.9174-0.0603-0.23270.17040.01360.1774-1.14250.01790.711-0.03720.3267-0.02630.02410.3772-0.0690.4525-10.910.087962.8917
116.0873-2.30332.25111.9251.07367.32-0.1914-0.7595-1.22350.59330.28490.11351.17230.21760.22920.65560.0728-0.0590.63620.11340.5246-22.6058-20.402686.8024
121.0439-0.21410.43253.67991.07842.68340.1449-0.4473-0.17010.4480.0604-0.67210.22990.52370.10670.41160.12530.00790.52580.07140.5625-12.5035-9.469483.6541
137.403-5.6812-3.29455.78650.62644.2489-0.1432-0.2182-1.22940.15970.07310.38531.4514-0.00840.20870.93220.125-0.00870.629-0.04610.8144-22.0409-25.349778.043
140.95910.2241-0.02472.178-0.07672.13660.15650.79810.2603-0.6798-0.11270.24280.1937-0.46570.11460.50030.1158-0.00450.62360.15910.381-22.3675-6.956174.3304
153.82181.8459-1.20532.7952-0.27635.26220.24690.6834-0.6127-0.4570.1235-0.94650.41970.02640.33320.7130.23330.1430.65780.04810.576-13.1047-16.730172.9986
169.8141-3.95891.12186.27954.62146.6137-0.21010.57190.2728-0.83670.2542-0.8921-0.34730.86530.08970.80750.15940.33660.71190.04360.8557-7.5717-10.597272.1115
174.63560.0931-4.01142.3229-1.08583.9064-0.2893-0.1873-0.5437-0.19550.2032-0.32540.3836-0.0719-0.05550.89110.08770.19420.5938-0.0070.9168-10.7671-0.697571.2339
181.1610.5893-1.09732.95350.40572.1231-0.04890.0682-0.1239-0.7288-0.0306-0.2482-0.1295-0.11510.0820.51680.0928-0.02740.4740.02490.3881-20.7889-8.587979.2331
199.45653.07590.3991.883-0.02623.4508-0.14380.011-0.3795-0.53-0.0034-0.20660.3447-0.23750.14120.52040.0489-0.01010.45090.05580.3036-28.4774-14.5284.0929
207.55112.6774-3.39751.0376-1.90417.0849-0.27-0.08040.30850.0688-0.1898-1.17410.28230.9140.0670.46730.0126-0.04680.5910.01970.653-11.2235-1.898182.6075
219.1926-2.23632.42022.3431-0.85979.318-0.5116-0.9914-0.070.8914-0.2352-0.5510.39280.47210.16780.34130.03450.05990.36690.08070.4283-15.2799-13.987355.2652
226.27214.66661.86813.8554-0.00635.6358-0.2363-0.5349-0.60330.60090.2476-0.09020.6282-0.17830.09730.6211-0.18130.06590.69830.01230.785-19.071-5.076358.8695
234.62692.4518-5.96323.2447-2.59417.84680.0615-0.228-0.36750.4983-0.2038-0.5497-0.00720.49790.07740.25620.01230.01120.26160.02230.3066-12.45932.734256.6481
242.3509-0.0957-0.33271.54260.40341.40590.05860.1544-0.0235-0.3107-0.1141-0.1262-0.0386-0.09370.03790.21560.02560.03190.2135-0.00430.3048-13.03-2.924344.7742
259.3468-0.833-4.95316.11763.03533.7550.2521.07220.0798-1.18440.1078-0.1556-0.3233-0.3329-0.02480.51050.04190.11320.39030.02230.4274-7.9772-2.832835.7944
263.59794.0986-1.62317.01130.73723.58680.04570.1843-0.4221-0.0347-0.3705-1.09810.8730.63450.05360.34980.05970.12870.26450.0050.5168-8.3166-12.284345.2553
271.38592.0384-1.31355.1906-0.43172.5418-0.05240.4706-0.0196-0.5751-0.1183-0.74540.2320.13420.11830.26490.03880.08520.27770.04420.4575-7.0363-2.364143.2992
285.67031.9796-1.30476.3733-2.56353.25380.00610.0774-0.0789-0.4162-0.5053-0.55550.24290.3725-0.0120.35840.03620.05370.27960.03660.3785-13.92777.514543.6786
292.56281.7393-0.19584.22710.3661.6163-0.0597-0.0593-0.08670.0019-0.15630.15570.1566-0.07890.08880.23940.00810.04850.2502-0.00820.3312-21.2193-7.673851.0733
302.9912-1.91790.67763.0122-1.26115.98150.2545-0.73020.73610.3285-0.2681-1.4117-1.38140.9530.15980.4839-0.16210.05380.4444-0.0360.5563-7.081111.555252.1672
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1CHAIN E AND RESID 132:136
2X-RAY DIFFRACTION2CHAIN E AND RESID 137:148
3X-RAY DIFFRACTION3CHAIN E AND RESID 149:162
4X-RAY DIFFRACTION4CHAIN E AND RESID 163:166
5X-RAY DIFFRACTION5CHAIN E AND RESID 167:175
6X-RAY DIFFRACTION6CHAIN E AND RESID 176:185
7X-RAY DIFFRACTION7CHAIN E AND RESID 186:190
8X-RAY DIFFRACTION8CHAIN E AND RESID 191:211
9X-RAY DIFFRACTION9CHAIN E AND RESID 212:219
10X-RAY DIFFRACTION10CHAIN E AND RESID 220:226
11X-RAY DIFFRACTION11CHAIN I AND RESID 132:136
12X-RAY DIFFRACTION12CHAIN I AND RESID 137:161
13X-RAY DIFFRACTION13CHAIN I AND RESID 162:165
14X-RAY DIFFRACTION14CHAIN I AND RESID 166:178
15X-RAY DIFFRACTION15CHAIN I AND RESID 179:192
16X-RAY DIFFRACTION16CHAIN I AND RESID 193:196
17X-RAY DIFFRACTION17CHAIN I AND RESID 197:200
18X-RAY DIFFRACTION18CHAIN I AND RESID 201:211
19X-RAY DIFFRACTION19CHAIN I AND RESID 212:219
20X-RAY DIFFRACTION20CHAIN I AND RESID 220:224
21X-RAY DIFFRACTION21CHAIN X AND RESID 132:137
22X-RAY DIFFRACTION22CHAIN X AND RESID 138:141
23X-RAY DIFFRACTION23CHAIN X AND RESID 142:147
24X-RAY DIFFRACTION24CHAIN X AND RESID 148:181
25X-RAY DIFFRACTION25CHAIN X AND RESID 182:185
26X-RAY DIFFRACTION26CHAIN X AND RESID 186:189
27X-RAY DIFFRACTION27CHAIN X AND RESID 190:197
28X-RAY DIFFRACTION28CHAIN X AND RESID 198:204
29X-RAY DIFFRACTION29CHAIN X AND RESID 205:222
30X-RAY DIFFRACTION30CHAIN X AND RESID 223:226

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