- PDB-4uwl: Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-o... -
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データベース: PDB / ID: 4uwl
タイトル
Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
要素
PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
Toll Like Receptor 9 (TLR9) Cascade / protein lipidation / Synthesis of PIPs at the late endosome membrane / phosphatidylinositol 3-kinase complex, class III / Synthesis of PIPs at the early endosome membrane / phosphatidylinositol 3-kinase complex, class III, type II / phosphatidylinositol 3-kinase complex, class III, type I / positive regulation by host of viral genome replication / Synthesis of PIPs at the Golgi membrane / phosphatidylinositol kinase activity ...Toll Like Receptor 9 (TLR9) Cascade / protein lipidation / Synthesis of PIPs at the late endosome membrane / phosphatidylinositol 3-kinase complex, class III / Synthesis of PIPs at the early endosome membrane / phosphatidylinositol 3-kinase complex, class III, type II / phosphatidylinositol 3-kinase complex, class III, type I / positive regulation by host of viral genome replication / Synthesis of PIPs at the Golgi membrane / phosphatidylinositol kinase activity / protein localization to phagophore assembly site / protein targeting to lysosome / early endosome to late endosome transport / phagophore assembly site / Translation of Replicase and Assembly of the Replication Transcription Complex / オートファゴソーム / PI3キナーゼ / phosphatidylinositol-3-phosphate biosynthetic process / オートファジー / 1-phosphatidylinositol-3-kinase activity / axoneme / phosphatidylinositol phosphate biosynthetic process / phosphatidylinositol-mediated signaling / autophagosome maturation / autophagosome assembly / PI3K Cascade / RHO GTPases Activate NADPH Oxidases / オートファゴソーム / regulation of macroautophagy / cellular response to glucose starvation / regulation of cytokinesis / regulation of autophagy / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / オートファジー / オートファジー / エンドサイトーシス / ペルオキシソーム / phagocytic vesicle membrane / late endosome / kinase activity / Translation of Replicase and Assembly of the Replication Transcription Complex / midbody / エンドソーム / protein kinase activity / 細胞周期 / リン酸化 / 細胞分裂 / SARS-CoV-2 activates/modulates innate and adaptive immune responses / ATP binding / 生体膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能