Entry Database : PDB / ID : 4fkd Structure visualization Downloads & linksTitle Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta ComponentsProtein kinase C theta type Details Keywords TRANSFERASE / PKC theta / second cysteine rich regulatory domain / activator binding site / zinc finger / KinaseFunction / homology Function and homology informationFunction Domain/homology Component
Netrin-1 signaling / positive regulation of T-helper 2 cell activation / Apoptotic cleavage of cellular proteins / Effects of PIP2 hydrolysis / calcium,diacylglycerol-dependent serine/threonine kinase activity / protein kinase C / FCERI mediated NF-kB activation / diacylglycerol-dependent serine/threonine kinase activity / Downstream TCR signaling / regulation of platelet aggregation ... Netrin-1 signaling / positive regulation of T-helper 2 cell activation / Apoptotic cleavage of cellular proteins / Effects of PIP2 hydrolysis / calcium,diacylglycerol-dependent serine/threonine kinase activity / protein kinase C / FCERI mediated NF-kB activation / diacylglycerol-dependent serine/threonine kinase activity / Downstream TCR signaling / regulation of platelet aggregation / negative regulation of T cell apoptotic process / positive regulation of T-helper 17 type immune response / aggresome / positive regulation of filopodium assembly / immune system process / positive regulation of interleukin-4 production / positive regulation of interleukin-17 production / positive regulation of telomere capping / membrane protein ectodomain proteolysis / centriolar satellite / immunological synapse / positive regulation of T cell proliferation / positive regulation of stress fiber assembly / positive regulation of telomerase activity / positive regulation of telomere maintenance via telomerase / regulation of G2/M transition of mitotic cell cycle / positive regulation of interleukin-2 production / negative regulation of insulin receptor signaling pathway / cell chemotaxis / positive regulation of protein secretion / neuromuscular junction / sarcolemma / positive regulation of protein import into nucleus / positive regulation of T cell activation / positive regulation of NF-kappaB transcription factor activity / peptidyl-serine phosphorylation / intracellular signal transduction / inflammatory response / protein phosphorylation / protein serine/threonine kinase activity / regulation of DNA-templated transcription / ATP binding / membrane / metal ion binding / nucleus / plasma membrane / cytoplasm Similarity search - Function Protein kinase C, theta / Novel protein kinase C theta, catalytic domain / Protein kinase C, delta/epsilon/eta/theta types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. ... Protein kinase C, theta / Novel protein kinase C theta, catalytic domain / Protein kinase C, delta/epsilon/eta/theta types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain profile. / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 1.633 Å DetailsAuthors Rahman, G.M. / Shanker, S. / Lewin, N.E. / Prasad, B.V.V. / Blumberg, P.M. / Das, J. CitationJournal : Biochem.J. / Year : 2013Title : Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta.Authors : Rahman, G.M. / Shanker, S. / Lewin, N.E. / Kedei, N. / Hill, C.S. / Prasad, B.V. / Blumberg, P.M. / Das, J. History Deposition Jun 13, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 23, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Jun 19, 2013 Group : Database referencesRevision 1.2 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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