Entry Database : PDB / ID : 3swc Structure visualization Downloads & linksTitle GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide ComponentsDNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3A Histone-lysine N-methyltransferase EHMT1 DetailsKeywords TRANSFERASE / epigenetics / non-histone lysine methylation / SET domain / protein lysine methyltransferaseFunction / homology Function and homology informationFunction Domain/homology Component
DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates / : / : / positive regulation of cellular response to hypoxia / PRC2 methylates histones and DNA / [histone H3]-lysine9 N-methyltransferase / epigenetic programming of gene expression / cellular response to bisphenol A / peptidyl-lysine monomethylation / protein-cysteine methyltransferase activity ... DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates / : / : / positive regulation of cellular response to hypoxia / PRC2 methylates histones and DNA / [histone H3]-lysine9 N-methyltransferase / epigenetic programming of gene expression / cellular response to bisphenol A / peptidyl-lysine monomethylation / protein-cysteine methyltransferase activity / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / peptidyl-lysine dimethylation / histone H3K27 methyltransferase activity / RMTs methylate histone arginines / genomic imprinting / DNA (cytosine-5-)-methyltransferase / unmethylated CpG binding / DNA (cytosine-5-)-methyltransferase activity / autosome genomic imprinting / : / DNA methylation-dependent heterochromatin formation / protein-lysine N-methyltransferase activity / XY body / cellular response to ethanol / C2H2 zinc finger domain binding / response to vitamin A / negative regulation of gene expression via chromosomal CpG island methylation / response to ionizing radiation / hepatocyte apoptotic process / Transcriptional Regulation by E2F6 / regulation of embryonic development / chromosome, centromeric region / catalytic complex / Transcriptional Regulation by VENTX / heterochromatin / response to fungicide / Transferases; Transferring one-carbon groups; Methyltransferases / transcription corepressor binding / response to cocaine / methyltransferase activity / cellular response to amino acid stimulus / response to lead ion / euchromatin / neuron differentiation / Regulation of TP53 Activity through Methylation / response to toxic substance / PKMTs methylate histone lysines / nuclear matrix / p53 binding / response to estradiol / positive regulation of cold-induced thermogenesis / chromatin organization / cellular response to hypoxia / Senescence-Associated Secretory Phenotype (SASP) / spermatogenesis / RNA polymerase II-specific DNA-binding transcription factor binding / nuclear body / response to xenobiotic stimulus / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of DNA-templated transcription / chromatin binding / chromatin / negative regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / metal ion binding / nucleus / cytoplasm Similarity search - Function Histone-lysine N-methyltransferase EHMT1 / DNA (cytosine-5)-methyltransferase 3A, ADD domain / Histone-lysine N-methyltransferase EHMT1/EHMT2 / : / Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region / : / DNMT3, ADD PHD zinc finger / DNMT3, cysteine rich ADD domain / DNMT3, cysteine rich ADD domain, GATA1-like zinc finger / ADD domain ... Histone-lysine N-methyltransferase EHMT1 / DNA (cytosine-5)-methyltransferase 3A, ADD domain / Histone-lysine N-methyltransferase EHMT1/EHMT2 / : / Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region / : / DNMT3, ADD PHD zinc finger / DNMT3, cysteine rich ADD domain / DNMT3, cysteine rich ADD domain, GATA1-like zinc finger / ADD domain / ADD domain profile. / Pre-SET domain / Pre-SET motif / Pre-SET domain profile. / N-terminal to some SET domains / DNA methylase, C-5 cytosine-specific, active site / C-5 cytosine-specific DNA methylases active site. / C-5 cytosine-specific DNA methylase (Dnmt) domain profile. / C-5 cytosine methyltransferase / C-5 cytosine-specific DNA methylase / Beta-clip-like / SET domain / Ankyrin repeats (many copies) / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / Beta Complex / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.332 Å DetailsAuthors Chang, Y. / Horton, J.R. / Zhang, X. / Cheng, X. CitationJournal : Nat Commun / Year : 2011Title : MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.Authors : Chang, Y. / Sun, L. / Kokura, K. / Horton, J.R. / Fukuda, M. / Espejo, A. / Izumi, V. / Koomen, J.M. / Bedford, M.T. / Zhang, X. / Shinkai, Y. / Fang, J. / Cheng, X. History Deposition Jul 13, 2011 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 30, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Sep 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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