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Yorodumi- PDB-3op0: Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGF... -
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-Basic information
Entry | Database: PDB / ID: 3op0 | ||||||
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Title | Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide | ||||||
Components |
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Keywords | SIGNALING PROTEIN/SIGNALING PROTEIN REGULATOR / Structural Genomics / Structural Genomics Consortium / SGC / Signal transduction protein / SH3-binding protein / SIGNALING PROTEIN-SIGNALING PROTEIN REGULATOR complex | ||||||
Function / homology | Function and homology information negative regulation of epidermal growth factor-activated receptor activity / response to hydroxyisoflavone / multivesicular body, internal vesicle lumen / positive regulation of prolactin secretion / negative regulation of cardiocyte differentiation / positive regulation of protein kinase C activity / diterpenoid metabolic process / Shc-EGFR complex / ovulation cycle / Inhibition of Signaling by Overexpressed EGFR ...negative regulation of epidermal growth factor-activated receptor activity / response to hydroxyisoflavone / multivesicular body, internal vesicle lumen / positive regulation of prolactin secretion / negative regulation of cardiocyte differentiation / positive regulation of protein kinase C activity / diterpenoid metabolic process / Shc-EGFR complex / ovulation cycle / Inhibition of Signaling by Overexpressed EGFR / epidermal growth factor receptor activity / EGFR interacts with phospholipase C-gamma / positive regulation of mucus secretion / response to UV-A / epidermal growth factor binding / PLCG1 events in ERBB2 signaling / tongue development / midgut development / ERBB2-EGFR signaling pathway / hydrogen peroxide metabolic process / PTK6 promotes HIF1A stabilization / digestive tract morphogenesis / regulation of nitric-oxide synthase activity / epidermal growth factor receptor binding / morphogenesis of an epithelial fold / ERBB2 Activates PTK6 Signaling / intracellular vesicle / Signaling by EGFR / response to cobalamin / transmembrane receptor protein tyrosine kinase activator activity / protein tyrosine kinase activator activity / negative regulation of epidermal growth factor receptor signaling pathway / Signaling by ERBB4 / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / eyelid development in camera-type eye / protein insertion into membrane / cerebral cortex cell migration / ERBB2 Regulates Cell Motility / regulation of JNK cascade / : / PI3K events in ERBB2 signaling / positive regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of mitotic cell cycle / hair follicle development / MAP kinase kinase kinase activity / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / embryonic placenta development / positive regulation of bone resorption / positive regulation of G1/S transition of mitotic cell cycle / GAB1 signalosome / positive regulation of nitric oxide mediated signal transduction / salivary gland morphogenesis / peptidyl-tyrosine autophosphorylation / regulation of peptidyl-tyrosine phosphorylation / positive regulation of phosphorylation / positive regulation of glial cell proliferation / positive regulation of vasoconstriction / Signaling by ERBB2 / cellular response to epidermal growth factor stimulus / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / cellular response to cadmium ion / positive regulation of DNA repair / EGFR Transactivation by Gastrin / GRB2 events in ERBB2 signaling / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / phosphotyrosine residue binding / transmembrane receptor protein tyrosine kinase activity / SHC1 events in ERBB2 signaling / ossification / positive regulation of synaptic transmission, glutamatergic / neurogenesis / cellular response to dexamethasone stimulus / basal plasma membrane / regulation of ERK1 and ERK2 cascade / neuron projection morphogenesis / positive regulation of superoxide anion generation / negative regulation of MAP kinase activity / positive regulation of DNA replication / Signal transduction by L1 / epithelial cell proliferation / cellular response to estradiol stimulus / NOTCH3 Activation and Transmission of Signal to the Nucleus / positive regulation of epithelial cell proliferation / astrocyte activation / liver regeneration / positive regulation of protein localization to plasma membrane / EGFR downregulation / cell surface receptor protein tyrosine kinase signaling pathway / cellular response to amino acid stimulus / positive regulation of smooth muscle cell proliferation / Signaling by ERBB2 TMD/JMD mutants / positive regulation of MAP kinase activity / clathrin-coated endocytic vesicle membrane / lung development / Constitutive Signaling by EGFRvIII / RING-type E3 ubiquitin transferase / Signaling by ERBB2 ECD mutants / epidermal growth factor receptor signaling pathway / Signaling by ERBB2 KD Mutants Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.52 Å | ||||||
Authors | Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. ...Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Bountra, C. / Bullock, A. / Structural Genomics Consortium (SGC) | ||||||
Citation | Journal: To be Published Title: Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide Authors: Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. / Arrowsmith, C.H. / Weigelt, J. / Edwards, ...Authors: Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Bountra, C. / Bullock, A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3op0.cif.gz | 283.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3op0.ent.gz | 229.3 KB | Display | PDB format |
PDBx/mmJSON format | 3op0.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/op/3op0 ftp://data.pdbj.org/pub/pdb/validation_reports/op/3op0 | HTTPS FTP |
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-Related structure data
Related structure data | 1fbvS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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