登録情報 | データベース: PDB / ID: 3o5z |
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タイトル | Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K) |
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要素 | Phosphatidylinositol 3-kinase regulatory subunit beta |
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キーワード | PROTEIN BINDING (タンパク質) / Src homology 3 domain (SH3ドメイン) |
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機能・相同性 | 機能・相同性情報
IRS-mediated signalling / regulation of actin filament polymerization / 1-phosphatidylinositol-3-kinase regulator activity / phosphatidylinositol 3-kinase regulatory subunit binding / RHOF GTPase cycle / regulation of stress fiber assembly / RHOD GTPase cycle / phosphatidylinositol 3-kinase complex, class IA / phosphatidylinositol 3-kinase complex / Nephrin family interactions ...IRS-mediated signalling / regulation of actin filament polymerization / 1-phosphatidylinositol-3-kinase regulator activity / phosphatidylinositol 3-kinase regulatory subunit binding / RHOF GTPase cycle / regulation of stress fiber assembly / RHOD GTPase cycle / phosphatidylinositol 3-kinase complex, class IA / phosphatidylinositol 3-kinase complex / Nephrin family interactions / RND1 GTPase cycle / Costimulation by the CD28 family / RND2 GTPase cycle / PI3K/AKT activation / RND3 GTPase cycle / negative regulation of MAPK cascade / RHOB GTPase cycle / Signaling by ALK / RHOJ GTPase cycle / intracellular glucose homeostasis / phosphatidylinositol phosphate biosynthetic process / CD28 dependent PI3K/Akt signaling / Synthesis of PIPs at the plasma membrane / CDC42 GTPase cycle / RHOU GTPase cycle / positive regulation of cell adhesion / T cell differentiation / RET signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / PI3K Cascade / RHOA GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / regulation of protein localization to plasma membrane / Interleukin receptor SHC signaling / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / GPVI-mediated activation cascade / Tie2 Signaling / RAC1 GTPase cycle / Interleukin-7 signaling / phosphotyrosine residue binding / response to endoplasmic reticulum stress / Downstream signal transduction / B cell differentiation / phosphatidylinositol 3-kinase/protein kinase B signal transduction / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / regulation of autophagy / Regulation of signaling by CBL / Signaling by SCF-KIT / receptor tyrosine kinase binding / VEGFA-VEGFR2 Pathway / positive regulation of protein import into nucleus / cellular response to insulin stimulus / Constitutive Signaling by Aberrant PI3K in Cancer / protein transport / Downstream TCR signaling / PIP3 activates AKT signaling / DAP12 signaling / insulin receptor signaling pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / G alpha (q) signalling events / protein phosphatase binding / Extra-nuclear estrogen signaling / 免疫応答 / protein heterodimerization activity / focal adhesion / positive regulation of transcription by RNA polymerase II / 細胞核 / 細胞質基質類似検索 - 分子機能 Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Rho GTPase activation protein ...Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Rho GTPase activation protein / SH3 Domains / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / SH3 type barrels. / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3ドメイン / Roll / Mainly Beta類似検索 - ドメイン・相同性 Phosphatidylinositol 3-kinase regulatory subunit beta類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.01 Å |
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データ登録者 | Chen, S. / Xiao, Y. / Ponnusamy, R. / Tan, J. / Lei, J. / Hilgenfeld, R. |
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引用 | ジャーナル: Acta Crystallogr.,Sect.F / 年: 2011 タイトル: X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit 著者: Chen, S. / Xiao, Y. / Ponnusamy, R. / Tan, J. / Lei, J. / Hilgenfeld, R. |
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履歴 | 登録 | 2010年7月28日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2011年8月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年11月9日 | Group: Database references |
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改定 1.2 | 2014年9月10日 | Group: Database references |
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