登録情報 | データベース: PDB / ID: 3laq |
---|
タイトル | Structure-based engineering of species selectivity in the uPA-uPAR interaction |
---|
要素 | - Urokinase plasminogen activator surface receptorUrokinase receptor
- Urokinase-type plasminogen activatorウロキナーゼ
|
---|
キーワード | Hydrolase/Hydrolase Receptor / uPA / uPAR / ATF / suPAR / smuPAR / mATF / Disulfide bond (ジスルフィド) / EGF-like domain (EGF様ドメイン) / Hydrolase (加水分解酵素) / Kringle / Plasminogen activation / Protease (プロテアーゼ) / Secreted (分泌) / Serine protease (セリンプロテアーゼ) / Zymogen (酵素前駆体) / Cell membrane (細胞膜) / Glycoprotein (糖タンパク質) / GPI-anchor (グリコシルホスファチジルイノシトール) / Lipoprotein (リポタンパク質) / Membrane (生体膜) / Receptor / Hydrolase-Hydrolase Receptor complex |
---|
機能・相同性 | 機能・相同性情報
Attachment of GPI anchor to uPAR / Dissolution of Fibrin Clot / regulation of hepatocyte proliferation / positive regulation of homotypic cell-cell adhesion / skeletal muscle tissue regeneration / mesenchymal cell differentiation / ウロキナーゼ / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation ...Attachment of GPI anchor to uPAR / Dissolution of Fibrin Clot / regulation of hepatocyte proliferation / positive regulation of homotypic cell-cell adhesion / skeletal muscle tissue regeneration / mesenchymal cell differentiation / ウロキナーゼ / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / epithelial cell differentiation involved in prostate gland development / regulation of fibrinolysis / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / serine-type endopeptidase complex / smooth muscle cell migration / positive regulation of epidermal growth factor receptor signaling pathway / plasminogen activation / positive regulation of smooth muscle cell migration / positive regulation of release of cytochrome c from mitochondria / regulation of cell adhesion mediated by integrin / negative regulation of fibrinolysis / regulation of cell adhesion / negative regulation of intrinsic apoptotic signaling pathway / serine protease inhibitor complex / fibrinolysis / Neutrophil degranulation / positive regulation of reactive oxygen species metabolic process / peptidase activity / regulation of cell population proliferation / 血管新生 / response to hypoxia / positive regulation of cell migration / positive regulation of protein phosphorylation / protein domain specific binding / external side of plasma membrane / signaling receptor binding / serine-type endopeptidase activity / positive regulation of cell population proliferation / negative regulation of apoptotic process / enzyme binding / 細胞膜 / extracellular space / extracellular region / 細胞膜類似検索 - 分子機能 CD59 antigen, conserved site / Ly-6 / u-PAR domain signature. / Ly-6 antigen / uPA receptor -like domain / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Plasminogen Kringle 4 / Plasminogen Kringle 4 / CD59 / CD59 / Snake toxin-like superfamily ...CD59 antigen, conserved site / Ly-6 / u-PAR domain signature. / Ly-6 antigen / uPA receptor -like domain / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Plasminogen Kringle 4 / Plasminogen Kringle 4 / CD59 / CD59 / Snake toxin-like superfamily / ラミニン / ラミニン / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF様ドメイン / リボン / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Βバレル / Mainly Beta類似検索 - ドメイン・相同性 ウロキナーゼ / Urokinase plasminogen activator surface receptor類似検索 - 構成要素 |
---|
生物種 | Mus musculus (ハツカネズミ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
---|
データ登録者 | Huang, M. |
---|
引用 | ジャーナル: J.Biol.Chem. / 年: 2010 タイトル: Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. 著者: Lin, L. / Gardsvoll, H. / Huai, Q. / Huang, M. / Ploug, M. |
---|
履歴 | 登録 | 2010年1月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2010年2月2日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Advisory / Refinement description / Version format compliance |
---|
改定 1.2 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
---|
|
---|