登録情報 | データベース: PDB / ID: 3fap |
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タイトル | ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP |
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要素 | - FK506-BINDING PROTEIN
- FKBP12-RAPAMYCIN ASSOCIATED PROTEIN
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キーワード | CELL CYCLE (細胞周期) / FKBP12 / FRAP / RAPAMYCIN (ラパマイシン) / COMPLEX / GENE THERAPY (遺伝子治療) |
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機能・相同性 | 機能・相同性情報
RNA polymerase III type 2 promoter sequence-specific DNA binding / positive regulation of cytoplasmic translational initiation / RNA polymerase III type 1 promoter sequence-specific DNA binding / positive regulation of pentose-phosphate shunt / T-helper 1 cell lineage commitment / regulation of locomotor rhythm / positive regulation of wound healing, spreading of epidermal cells / cellular response to leucine starvation / TORC2 complex / regulation of membrane permeability ...RNA polymerase III type 2 promoter sequence-specific DNA binding / positive regulation of cytoplasmic translational initiation / RNA polymerase III type 1 promoter sequence-specific DNA binding / positive regulation of pentose-phosphate shunt / T-helper 1 cell lineage commitment / regulation of locomotor rhythm / positive regulation of wound healing, spreading of epidermal cells / cellular response to leucine starvation / TORC2 complex / regulation of membrane permeability / heart valve morphogenesis / TFIIIC-class transcription factor complex binding / negative regulation of lysosome organization / macrolide binding / RNA polymerase III type 3 promoter sequence-specific DNA binding / TORC1 complex / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / calcineurin-NFAT signaling cascade / activin receptor binding / cytoplasmic side of membrane / regulation of autophagosome assembly / nucleus localization / TORC1 signaling / voluntary musculoskeletal movement / regulation of osteoclast differentiation / positive regulation of keratinocyte migration / signaling receptor inhibitor activity / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / cellular response to L-leucine / MTOR signalling / Amino acids regulate mTORC1 / cellular response to nutrient / type I transforming growth factor beta receptor binding / energy reserve metabolic process / Energy dependent regulation of mTOR by LKB1-AMPK / negative regulation of activin receptor signaling pathway / ruffle organization / negative regulation of cell size / heart trabecula formation / cellular response to osmotic stress / terminal cisterna / ryanodine receptor complex / I-SMAD binding / anoikis / regulation of amyloid precursor protein catabolic process / negative regulation of protein localization to nucleus / cardiac muscle cell development / positive regulation of transcription by RNA polymerase III / protein maturation by protein folding / negative regulation of calcineurin-NFAT signaling cascade / 'de novo' protein folding / regulation of myelination / ventricular cardiac muscle tissue morphogenesis / regulation of cell size / negative regulation of macroautophagy / オートファジー / negative regulation of phosphoprotein phosphatase activity / positive regulation of oligodendrocyte differentiation / lysosome organization / FK506 binding / positive regulation of actin filament polymerization / positive regulation of myotube differentiation / behavioral response to pain / oligodendrocyte differentiation / mTORC1-mediated signalling / TGF-beta receptor signaling activates SMADs / Constitutive Signaling by AKT1 E17K in Cancer / germ cell development / CD28 dependent PI3K/Akt signaling / positive regulation of phosphoprotein phosphatase activity / cellular response to nutrient levels / Calcineurin activates NFAT / HSF1-dependent transactivation / MTOR / regulation of immune response / neuronal action potential / regulation of macroautophagy / positive regulation of translational initiation / 細胞内膜系 / response to amino acid / 'de novo' pyrimidine nucleobase biosynthetic process / positive regulation of lamellipodium assembly / protein peptidyl-prolyl isomerization / positive regulation of epithelial to mesenchymal transition / supramolecular fiber organization / positive regulation of lipid biosynthetic process / regulation of cellular response to heat / heart morphogenesis / cardiac muscle contraction / regulation of ryanodine-sensitive calcium-release channel activity / phagocytic vesicle / positive regulation of stress fiber assembly / cytoskeleton organization / sarcoplasmic reticulum membrane / T cell costimulation / T細胞 / cellular response to amino acid starvation / cellular response to starvation / positive regulation of glycolytic process類似検索 - 分子機能 FKBP12-rapamycin binding domain / Domain of unknown function DUF3385, target of rapamycin protein / Serine/threonine-protein kinase mTOR domain / Domain of unknown function / FKBP12-rapamycin binding domain / Serine/threonine-protein kinase TOR / FKBP12-rapamycin binding domain superfamily / FKBP12-rapamycin binding domain / Rapamycin binding domain / PIK-related kinase, FAT ...FKBP12-rapamycin binding domain / Domain of unknown function DUF3385, target of rapamycin protein / Serine/threonine-protein kinase mTOR domain / Domain of unknown function / FKBP12-rapamycin binding domain / Serine/threonine-protein kinase TOR / FKBP12-rapamycin binding domain superfamily / FKBP12-rapamycin binding domain / Rapamycin binding domain / PIK-related kinase, FAT / FAT domain / FATC domain / FATC / FATC domain / PIK-related kinase / FAT domain profile. / FATC domain profile. / Chitinase A; domain 3 - #40 / Chitinase A; domain 3 / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / FKBP-type peptidyl-prolyl cis-trans isomerase domain / FKBP-type peptidyl-prolyl cis-trans isomerase / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / Peptidyl-prolyl cis-trans isomerase domain superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / Armadillo-like helical / Tetratricopeptide-like helical domain superfamily / Armadillo-type fold / Roll / Protein kinase-like domain superfamily / Up-down Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 C15-(R)-METHYLTHIENYL RAPAMYCIN / Serine/threonine-protein kinase mTOR / Peptidyl-prolyl cis-trans isomerase FKBP1A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.85 Å |
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データ登録者 | Liang, J. / Clardy, J. |
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引用 | ジャーナル: Acta Crystallogr.,Sect.D / 年: 1999 タイトル: Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. 著者: Liang, J. / Choi, J. / Clardy, J. |
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履歴 | 登録 | 1999年5月6日 | 登録サイト: BNL / 処理サイト: RCSB |
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改定 1.0 | 2000年9月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月26日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2023年9月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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