[English] 日本語
![](img/lk-miru.gif)
- PDB-3cp1: Structure of a longer thermalstable core domain of HIV-1 gp41 con... -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 3cp1 | ||||||
---|---|---|---|---|---|---|---|
Title | Structure of a longer thermalstable core domain of HIV-1 gp41 containing the enfuvirtide resistance mutation N43D | ||||||
![]() | Transmembrane Protein![]() | ||||||
![]() | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() | ||||||
Function / homology | ![]() Dectin-2 family / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Wang, Z.M. / Dwyer, J.J. | ||||||
![]() | ![]() Title: Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Authors: Bai, X. / Wilson, K.L. / Seedorff, J.E. / Ahrens, D. / Green, J. / Davison, D.K. / Jin, L. / Stanfield-Oakley, S.A. / Mosier, S.M. / Melby, T.E. / Cammack, N. / Wang, Z. / Greenberg, M.L. / Dwyer, J.J. | ||||||
History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 26.7 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 17.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
---|
-Related structure data
Related structure data | ![]() 2ot5C ![]() 3cyoC ![]() 1envS S: Starting model for refinement C: citing same article ( |
---|---|
Similar structure data |
-
Links
-
Assembly
Deposited unit | ![]()
| ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | ![]()
| ||||||||||||
Unit cell |
| ||||||||||||
Components on special symmetry positions |
|
-
Components
#1: Protein | ![]() Mass: 9975.124 Da / Num. of mol.: 1 Fragment: Fusion protein of UNP residues 536-579, Linker, and UNP residues 628-663 Mutation: N43D Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() ![]() |
---|---|
#2: Water | ChemComp-HOH / ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 1.76 Å3/Da / Density % sol: 30.16 % |
---|---|
Crystal grow![]() | Temperature: 295 K / Method: vapor diffusion, sitting drop / pH: 7.5 Details: 25-40% ethylene glycol, 0.2 M MgCl2 and 0.1 M HEPES pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K |
-Data collection
Diffraction | Mean temperature: 100 K |
---|---|
Diffraction source | Source: ![]() |
Detector | Type: RIGAKU RAXIS IV / Detector: IMAGE PLATE / Date: Mar 1, 2007 / Details: mirrors |
Radiation | Monochromator: GRAPHITE / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.95→19.84 Å / Num. all: 5312 / Num. obs: 4896 / % possible obs: 91.3 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 / Rsym value: 0.089 / Net I/σ(I): 8 |
Reflection shell | Resolution: 1.95→2.02 Å / Rmerge(I) obs: 0.827 / % possible all: 21.1 |
-
Processing
Software |
| |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Method to determine structure![]() ![]() Starting model: PDB entry 1ENV Resolution: 2→19.84 Å / Isotropic thermal model: anisotropic / Cross valid method: THROUGHOUT / σ(F): 0 / σ(I): 0 / Stereochemistry target values: Engh & Huber
| |||||||||||||||||||||||||
Displacement parameters |
| |||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2→19.84 Å
|