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- PDB-2z7r: Crystal Structure of the N-terminal Kinase Domain of Human RSK1 b... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2z7r | ||||||
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Title | Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine | ||||||
![]() | Ribosomal protein S6 kinase alpha-1![]() | ||||||
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Function / homology | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Ikuta, M. / Munshi, S.K. | ||||||
![]() | ![]() Title: Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Authors: Ikuta, M. / Kornienko, M. / Byrne, N. / Reid, J.C. / Mizuarai, S. / Kotani, H. / Munshi, S.K. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 71.6 KB | Display | ![]() |
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PDB format | ![]() | 51.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 2z7qC ![]() 2z7sC ![]() 1vzoS C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 36777.391 Da / Num. of mol.: 1 / Fragment: Residues 33-353 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: Q15418, ![]() |
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#2: Chemical | ChemComp-STU / ![]() |
#3: Water | ChemComp-HOH / ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.3 Å3/Da / Density % sol: 46.41 % |
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Crystal grow![]() | Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 7.5 Details: 12-16% PEG MME 2000, 150mM DL-malic acid, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 210 / Detector: CCD / Date: Jul 27, 2006 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Resolution: 2→50 Å / Num. obs: 23744 / % possible obs: 98.6 % / Redundancy: 6 % / Biso Wilson estimate: 31.2 Å2 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 1VZO Resolution: 2→20 Å
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Refinement step | Cycle: LAST / Resolution: 2→20 Å
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