Entry | Database: PDB / ID: 2vv9 |
---|
Title | CDK2 in complex with an imidazole piperazine |
---|
Components | CELL DIVISION PROTEIN KINASE 2 |
---|
Keywords | TRANSFERASE / KINASE / MITOSIS / CELL CYCLE / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / CELL DIVISION / PHOSPHOPROTEIN / PHOSPHORYLATION / NUCLEOTIDE-BINDING |
---|
Function / homology | Function and homology information
Replication initiator protein RctB, central region / RctB, helix turn helix domain / Vibrionales, replication initiator protein RctB, central region / RctB helix turn helix domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / 2-Layer Sandwich ...Replication initiator protein RctB, central region / RctB, helix turn helix domain / Vibrionales, replication initiator protein RctB, central region / RctB helix turn helix domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | HOMO SAPIENS (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.9 Å |
---|
Authors | Acton, D.G. / Anderson, M. / Andrews, D.M. / Barker, A.J. / Brassington, C.A. / Finlay, M.R. / Fisher, E. / Gerhardt, S. / Graham, M.A. / Green, C.P. ...Acton, D.G. / Anderson, M. / Andrews, D.M. / Barker, A.J. / Brassington, C.A. / Finlay, M.R. / Fisher, E. / Gerhardt, S. / Graham, M.A. / Green, C.P. / Heaton, D.W. / Loddick, S.A. / Morgentin, R. / Read, J. / Roberts, A. / Stanway, J. / Tucker, J.A. / Weir, H.M. |
---|
Citation | Journal: Bioorg.Med.Chem.Lett. / Year: 2008 Title: Imidazole Piperazines: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors with a Novel Binding Mode. Authors: Finlay, M.R. / Acton, D.G. / Andrews, D.M. / Barker, A.J. / Dennis, M. / Fisher, E. / Graham, M.A. / Green, C.P. / Heaton, D.W. / Karoutchi, G. / Loddick, S.A. / Morgentin, R. / Roberts, A. ...Authors: Finlay, M.R. / Acton, D.G. / Andrews, D.M. / Barker, A.J. / Dennis, M. / Fisher, E. / Graham, M.A. / Green, C.P. / Heaton, D.W. / Karoutchi, G. / Loddick, S.A. / Morgentin, R. / Roberts, A. / Tucker, J.A. / Weir, H.M. |
---|
History | Deposition | Jun 4, 2008 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Aug 5, 2008 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
---|
Revision 1.2 | Apr 24, 2019 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Other / Source and taxonomy Category: entity_src_gen / pdbx_database_proc ...entity_src_gen / pdbx_database_proc / pdbx_database_status / struct_conn Item: _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag |
---|
Revision 1.3 | May 1, 2024 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
---|
|
---|