登録情報 データベース : PDB / ID : 2rqb 構造の表示 ダウンロードとリンクタイトル Solution structure of MDA5 CTD 要素Interferon-induced helicase C domain-containing protein 1 詳細 キーワード HYDROLASE (加水分解酵素) / RNA binding protein (RNA結合タンパク質) / Alternative splicing (選択的スプライシング) / Antiviral defense / ATP-binding / Cytoplasm (細胞質) / Diabetes mellitus (糖尿病) / Helicase (ヘリカーゼ) / Host-virus interaction / Immune response (免疫応答) / Innate immunity (自然免疫系) / Nucleotide-binding / Nucleus (Nucleus) / Phosphoprotein / Polymorphism / RNA-binding機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
MDA-5 signaling pathway / regulation of type III interferon production / detection of virus / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / positive regulation of response to cytokine stimulus / pattern recognition receptor activity / TRAF6 mediated IRF7 activation / negative regulation of viral genome replication / type I interferon-mediated signaling pathway / cytoplasmic pattern recognition receptor signaling pathway ... MDA-5 signaling pathway / regulation of type III interferon production / detection of virus / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / positive regulation of response to cytokine stimulus / pattern recognition receptor activity / TRAF6 mediated IRF7 activation / negative regulation of viral genome replication / type I interferon-mediated signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / antiviral innate immune response / TRAF6 mediated NF-kB activation / protein sumoylation / positive regulation of interferon-alpha production / ribonucleoprotein complex binding / positive regulation of interferon-beta production / Negative regulators of DDX58/IFIH1 signaling / response to virus / DDX58/IFIH1-mediated induction of interferon-alpha/beta / cellular response to virus / positive regulation of interleukin-6 production / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of tumor necrosis factor production / double-stranded RNA binding / Ovarian tumor domain proteases / protein complex oligomerization / TRAF3-dependent IRF activation pathway / defense response to virus / RNA helicase activity / single-stranded RNA binding / Ub-specific processing proteases / ヘリカーゼ / 自然免疫系 / SARS-CoV-2 activates/modulates innate and adaptive immune responses / ATP hydrolysis activity / ミトコンドリア / DNA binding / RNA binding / zinc ion binding / ATP binding / identical protein binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 RIG-I-like receptor, C-terminal regulatory domain / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / RIG-I-like receptor, C-terminal / RIG-I receptor C-terminal domain / RIG-I-like receptor, C-terminal regulatory domain / RIG-I-like receptor, C-terminal domain superfamily / C-terminal domain of RIG-I / RIG-I-like receptor (RLR) C-terminal regulatory (CTR) domain profile. / Caspase recruitment domain / Caspase recruitment domain ... RIG-I-like receptor, C-terminal regulatory domain / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / RIG-I-like receptor, C-terminal / RIG-I receptor C-terminal domain / RIG-I-like receptor, C-terminal regulatory domain / RIG-I-like receptor, C-terminal domain superfamily / C-terminal domain of RIG-I / RIG-I-like receptor (RLR) C-terminal regulatory (CTR) domain profile. / Caspase recruitment domain / Caspase recruitment domain / Helicase/UvrB, N-terminal / Type III restriction enzyme, res subunit / Death-like domain superfamily / Beta Complex / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta 類似検索 - ドメイン・相同性 Interferon-induced helicase C domain-containing protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細Model details lowest energy, model 1 データ登録者 Takahasi, K. / Kumeta, H. / Tsuduki, N. / Narita, R. / Shigemoto, T. / Hirai, R. / Yoneyama, M. / Horiuchi, M. / Ogura, K. / Fujita, T. / Fuyuhiko, I. 引用ジャーナル : J.Biol.Chem. / 年 : 2009タイトル : Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS著者 : Takahasi, K. / Kumeta, H. / Tsuduki, N. / Narita, R. / Shigemoto, T. / Hirai, R. / Yoneyama, M. / Horiuchi, M. / Ogura, K. / Fujita, T. / Inagaki, F. 履歴 登録 2009年3月17日 登録サイト : BMRB / 処理サイト : PDBJ改定 1.0 2009年5月5日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2022年3月16日 Group : Database references / Derived calculationsカテゴリ : database_2 / pdbx_struct_assembly ... database_2 / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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