登録情報 | データベース: PDB / ID: 2qyk |
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タイトル | Crystal structure of PDE4A10 in complex with inhibitor NPV |
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要素 | Cyclic AMP-specific phosphodiesterase HSPDE4A10 |
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キーワード | HYDROLASE (加水分解酵素) / PDE4 inhibitor / subfamily inhibitor selectivity |
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機能・相同性 | 機能・相同性情報
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / cellular response to xenobiotic stimulus => GO:0071466 / 3',5'-cyclic-AMP phosphodiesterase / regulation of protein kinase A signaling / extrinsic component of membrane / cAMP catabolic process / 3',5'-cyclic-AMP phosphodiesterase activity / DARPP-32 events / regulation of cAMP-mediated signaling / cAMP binding ...regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / cellular response to xenobiotic stimulus => GO:0071466 / 3',5'-cyclic-AMP phosphodiesterase / regulation of protein kinase A signaling / extrinsic component of membrane / cAMP catabolic process / 3',5'-cyclic-AMP phosphodiesterase activity / DARPP-32 events / regulation of cAMP-mediated signaling / cAMP binding / ruffle membrane / sensory perception of smell / cellular response to xenobiotic stimulus / G alpha (s) signalling events / G protein-coupled receptor signaling pathway / perinuclear region of cytoplasm / シグナル伝達 / 核質 / 生体膜 / metal ion binding / 細胞核 / 細胞膜 / 細胞質基質類似検索 - 分子機能 Phosphodiesterase 4 upstream conserved regions (UCR) / Phosphodiesterase 4 upstream conserved regions (UCR) / Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. ...Phosphodiesterase 4 upstream conserved regions (UCR) / Phosphodiesterase 4 upstream conserved regions (UCR) / Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-NPV / 3',5'-cyclic-AMP phosphodiesterase 4A / cAMP-specific 3',5'-cyclic phosphodiesterase 4A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Wang, H. / Peng, M. / Chen, Y. / Geng, J. / Robinson, H. / Houslay, M. |
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引用 | ジャーナル: Biochem.J. / 年: 2007 タイトル: Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. 著者: Wang, H. / Peng, M.S. / Chen, Y. / Geng, J. / Robinson, H. / Houslay, M.D. / Cai, J. / Ke, H. |
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履歴 | 登録 | 2007年8月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年4月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2024年2月21日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.3 | 2024年4月3日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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