登録情報 | データベース: PDB / ID: 2qwn |
---|
タイトル | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-386aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi state |
---|
要素 | - Heat shock cognate 71 kDa protein
- Putative tyrosine-protein phosphatase auxilin
|
---|
キーワード | CHAPERONE (シャペロン) / chaperone-cochaperone complex / ATP-binding / Nucleotide-binding / Nucleus (Nucleus) / Phosphorylation (リン酸化) / Stress response (闘争・逃走反応) / Hydrolase (加水分解酵素) / Protein phosphatase (プロテインホスファターゼ) / SH3-binding |
---|
機能・相同性 | 機能・相同性情報
regulation of clathrin coat assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / HSF1-dependent transactivation / Protein methylation / GABA synthesis, release, reuptake and degradation / PKR-mediated signaling / mRNA Splicing - Major Pathway / シナプス小胞 / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ...regulation of clathrin coat assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / HSF1-dependent transactivation / Protein methylation / GABA synthesis, release, reuptake and degradation / PKR-mediated signaling / mRNA Splicing - Major Pathway / シナプス小胞 / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / chaperone-mediated autophagy translocation complex disassembly / slow axonal transport / clathrin-uncoating ATPase activity / protein targeting to lysosome involved in chaperone-mediated autophagy / clathrin heavy chain binding / late endosomal microautophagy / synaptic vesicle uncoating / AUF1 (hnRNP D0) binds and destabilizes mRNA / clathrin coat disassembly / 加水分解酵素; エステル加水分解酵素; 1価のリン酸エステル加水分解酵素 / Clathrin-mediated endocytosis / clathrin-dependent endocytosis / Prp19 complex / presynaptic cytosol / クラスリン / postsynaptic cytosol / Neutrophil degranulation / clathrin binding / non-chaperonin molecular chaperone ATPase / chaperone cofactor-dependent protein refolding / intracellular transport / オートファゴソーム / 脱リン酸化 / protein folding chaperone / heat shock protein binding / RNA splicing / protein tyrosine phosphatase activity / ATP-dependent protein folding chaperone / spliceosomal complex / terminal bouton / 転写後修飾 / SH3 domain binding / メラノソーム / presynapse / protein-macromolecule adaptor activity / protein refolding / vesicle / postsynaptic density / molecular adaptor activity / ribonucleoprotein complex / lysosomal membrane / protein domain specific binding / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / 樹状突起 / 核小体 / ATP hydrolysis activity / ATP binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / DnaJ domain / Defensin A-like - #30 / DnaJ molecular chaperone homology domain / dnaJ domain profile. ...Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / DnaJ domain / Defensin A-like - #30 / DnaJ molecular chaperone homology domain / dnaJ domain profile. / Chaperone J-domain superfamily / DnaJ domain / Defensin A-like / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / C2 domain superfamily / ATPase, nucleotide binding domain / Helix Hairpins / Nucleotidyltransferase; domain 5 / Alpha-Beta Complex / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / リン酸塩 / Heat shock cognate 71 kDa protein / Auxilin類似検索 - 構成要素 |
---|
生物種 | ![](img/tx_mammal.gif) ![](data/taxo/icon/Bos_taurus_S.png) Bos taurus (ウシ) |
---|
手法 | X線回折 / 分子置換 / 解像度: 2.4 Å |
---|
データ登録者 | Jiang, J. / Maes, E.G. / Wang, L. / Taylor, A.B. / Hinck, A.P. / Lafer, E.M. / Sousa, R. |
---|
引用 | ジャーナル: Mol.Cell / 年: 2007 タイトル: Structural basis of J cochaperone binding and regulation of Hsp70. 著者: Jiang, J. / Maes, E.G. / Taylor, A.B. / Wang, L. / Hinck, A.P. / Lafer, E.M. / Sousa, R. |
---|
履歴 | 登録 | 2007年8月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2007年12月18日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Advisory / Refinement description / Version format compliance |
---|
改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version |
---|
改定 1.3 | 2021年10月20日 | Group: Database references / Derived calculations カテゴリ: database_2 / pdbx_struct_conn_angle ...database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|