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Yorodumi- PDB-2mtw: Evidence supporting the hypothesis that specifically modifying a ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2mtw | ||||||
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Title | Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DR 1*03 molecules induces antibody production and protection | ||||||
Components | Erythrocyte-binding antigen 175 | ||||||
Keywords | PROTEIN BINDING / EBA-175 | ||||||
Function / homology | Function and homology information leukocyte migration / : / Cell surface interactions at the vascular wall / membrane => GO:0016020 / host cell surface receptor binding / plasma membrane Similarity search - Function | ||||||
Biological species | Plasmodium falciparum CAMP/Malaysia (eukaryote) | ||||||
Method | SOLUTION NMR / distance geometry, DGSA-distance geometry simulated annealing | ||||||
Model details | lowest energy, model7 | ||||||
Authors | Cifuentes, G. / Salazar, L. / Vargas, L. / Parra, C. / Vanegas, M. / Cortes, J. / Sandoval, M. / Patarroyo, M.E. | ||||||
Citation | Journal: To be Published Title: Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit HLA-DR 1*03 molecules induces antibody production and protection Authors: Cifuentes, G. / Salazar, L. / Vargas, L. / Parra, C. / Vanegas, M. / Cortes, J. / Sandoval, M. / Patarroyo, M.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2mtw.cif.gz | 14.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2mtw.ent.gz | 8.2 KB | Display | PDB format |
PDBx/mmJSON format | 2mtw.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/mt/2mtw ftp://data.pdbj.org/pub/pdb/validation_reports/mt/2mtw | HTTPS FTP |
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-Related structure data
Similar structure data | |
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Other databases |
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 2446.633 Da / Num. of mol.: 1 / Fragment: UNP residues 1221-1239 / Source method: obtained synthetically Source: (synth.) Plasmodium falciparum CAMP/Malaysia (eukaryote) References: UniProt: P19214 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||
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NMR experiment |
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-Sample preparation
Details | Contents: 8 mM DMSO, DMSO / Solvent system: DMSO |
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Sample | Conc.: 8 mM / Component: DMSO-1 |
Sample conditions | pH: 3.7 / Pressure: ambient / Temperature: 295 K |
-NMR measurement
NMR spectrometer | Type: Bruker DRX / Manufacturer: Bruker / Model: DRX / Field strength: 600 MHz |
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-Processing
NMR software |
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Refinement | Method: distance geometry, DGSA-distance geometry simulated annealing Software ordinal: 1 | |||||||||
NMR representative | Selection criteria: lowest energy | |||||||||
NMR ensemble | Conformer selection criteria: structures with the least restraint violations Conformers calculated total number: 50 / Conformers submitted total number: 1 / Representative conformer: 7 |