登録情報 | データベース: PDB / ID: 2mh0 |
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タイトル | Solution NMR structure of the p300 Taz2:ETAD1 complex |
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要素 | - Histone acetyltransferase p300
- Transcription factor E2-alpha
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キーワード | TRANSCRIPTION/TRANSFERASE / TRANSCRIPTION-TRANSFERASE complex |
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機能・相同性 | 機能・相同性情報
behavioral defense response / protein propionyltransferase activity / peptidyl-lysine propionylation / histone lactyltransferase activity / peptidyl-lysine crotonylation / peptidyl-lysine butyrylation / histone butyryltransferase activity / histone H3K122 acetyltransferase activity / 水泳 / peptide butyryltransferase activity ...behavioral defense response / protein propionyltransferase activity / peptidyl-lysine propionylation / histone lactyltransferase activity / peptidyl-lysine crotonylation / peptidyl-lysine butyrylation / histone butyryltransferase activity / histone H3K122 acetyltransferase activity / 水泳 / peptide butyryltransferase activity / histone H2B acetyltransferase activity / 走性 / peptide 2-hydroxyisobutyryltransferase activity / histone crotonyltransferase activity / bHLH transcription factor binding / NOTCH2 intracellular domain regulates transcription / peptidyl-lysine acetylation / lysine N-acetyltransferase activity, acting on acetyl phosphate as donor / histone H4 acetyltransferase activity / immunoglobulin V(D)J recombination / cellular response to L-leucine / vitamin D response element binding / internal peptidyl-lysine acetylation / histone H3 acetyltransferase activity / NFE2L2 regulating ER-stress associated genes / peptide N-acetyltransferase activity / acetylation-dependent protein binding / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / NGF-stimulated transcription / mitogen-activated protein kinase kinase kinase binding / STAT3 nuclear events downstream of ALK signaling / Polo-like kinase mediated events / histone H3K18 acetyltransferase activity / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / NFE2L2 regulates pentose phosphate pathway genes / NFE2L2 regulating MDR associated enzymes / regulation of androgen receptor signaling pathway / positive regulation by host of viral transcription / regulation of mitochondrion organization / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / RUNX3 regulates NOTCH signaling / face morphogenesis / NOTCH4 Intracellular Domain Regulates Transcription / Regulation of FOXO transcriptional activity by acetylation / Regulation of gene expression by Hypoxia-inducible Factor / regulation of glycolytic process / Nuclear events mediated by NFE2L2 / Regulation of NFE2L2 gene expression / NOTCH3 Intracellular Domain Regulates Transcription / platelet formation / NFE2L2 regulating anti-oxidant/detoxification enzymes / TRAF6 mediated IRF7 activation / megakaryocyte development / nuclear androgen receptor binding / regulation of tubulin deacetylation / macrophage derived foam cell differentiation / FOXO-mediated transcription of cell death genes / NFE2L2 regulating tumorigenic genes / peptide-lysine-N-acetyltransferase activity / STAT family protein binding / internal protein amino acid acetylation / acyltransferase activity / protein acetylation / B cell lineage commitment / Myogenesis / fat cell differentiation / Formation of paraxial mesoderm / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / E-box binding / positive regulation of transforming growth factor beta receptor signaling pathway / PI5P Regulates TP53 Acetylation / regulation of G1/S transition of mitotic cell cycle / Zygotic genome activation (ZGA) / stimulatory C-type lectin receptor signaling pathway / acetyltransferase activity / cellular response to nutrient levels / RUNX3 regulates p14-ARF / NF-kappaB binding / histone acetyltransferase complex / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / Attenuation phase / canonical NF-kappaB signal transduction / negative regulation of protein-containing complex assembly / cis-regulatory region sequence-specific DNA binding / negative regulation of gluconeogenesis / somitogenesis / positive regulation of cell cycle / positive regulation of T-helper 17 cell lineage commitment / pre-mRNA intronic binding / regulation of cellular response to heat / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / histone acetyltransferase activity / positive regulation of B cell proliferation / skeletal muscle tissue development / ヒストンアセチルトランスフェラーゼ / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / transcription initiation-coupled chromatin remodeling類似検索 - 分子機能 CREB-binding Protein; Chain A / TAZ domain / Helix-loop-helix DNA-binding domain / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. ...CREB-binding Protein; Chain A / TAZ domain / Helix-loop-helix DNA-binding domain / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Coactivator CBP, KIX domain superfamily / Histone acetylation protein / Histone acetylation protein / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Nuclear receptor coactivator, interlocking / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Transcription factor E2-alpha / Histone acetyltransferase p300類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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Model details | lowest energy, model1 |
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データ登録者 | Langelaan, D.N. / Smith, S.P. / Chitayat, S. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2020 タイトル: Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A. 著者: Lochhead, M.R. / Brown, A.D. / Kirlin, A.C. / Chitayat, S. / Munro, K. / Findlay, J.E. / Baillie, G.S. / LeBrun, D.P. / Langelaan, D.N. / Smith, S.P. |
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履歴 | 登録 | 2013年11月12日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2014年11月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年8月24日 | Group: Data collection / Database references カテゴリ: citation / citation_author ...citation / citation_author / database_2 / pdbx_nmr_software / struct_ref_seq_dif Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq_dif.details |
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改定 1.2 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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