登録情報 | データベース: PDB / ID: 2lsp |
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タイトル | solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide |
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要素 | - Bromodomain-containing protein 4BRD4
- NF-kB-K310ac peptide
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キーワード | PROTEIN BINDING (タンパク質) / NF-kB (NF-κB) / BRD4 (BRD4) / HIV (ヒト免疫不全ウイルス) / bromodomain (ブロモドメイン) / kidney disease |
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機能・相同性 | 機能・相同性情報
acetaldehyde metabolic process / prolactin signaling pathway / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / NF-kappaB p50/p65 complex / IkBA variant leads to EDA-ID / positive regulation of Schwann cell differentiation / cellular response to peptidoglycan / Regulated proteolysis of p75NTR / ankyrin repeat binding / RIP-mediated NFkB activation via ZBP1 ...acetaldehyde metabolic process / prolactin signaling pathway / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / NF-kappaB p50/p65 complex / IkBA variant leads to EDA-ID / positive regulation of Schwann cell differentiation / cellular response to peptidoglycan / Regulated proteolysis of p75NTR / ankyrin repeat binding / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / CLEC7A/inflammasome pathway / negative regulation of protein sumoylation / postsynapse to nucleus signaling pathway / defense response to tumor cell / nucleotide-binding oligomerization domain containing 2 signaling pathway / Interleukin-1 processing / cellular response to interleukin-6 / actinin binding / NF-kappaB complex / negative regulation of non-canonical NF-kappaB signal transduction / cellular response to angiotensin / response to UV-B / vascular endothelial growth factor signaling pathway / interleukin-1-mediated signaling pathway / Regulation of NFE2L2 gene expression / positive regulation of leukocyte adhesion to vascular endothelial cell / positive regulation of miRNA metabolic process / toll-like receptor 4 signaling pathway / cellular response to hepatocyte growth factor stimulus / positive regulation of amyloid-beta formation / positive regulation of T cell receptor signaling pathway / response to cobalamin / phosphate ion binding / non-canonical NF-kappaB signal transduction / cellular response to lipoteichoic acid / TRAF6 mediated NF-kB activation / response to muramyl dipeptide / RNA polymerase II C-terminal domain binding / The NLRP3 inflammasome / negative regulation of DNA damage checkpoint / general transcription initiation factor binding / P-TEFb complex binding / Transcriptional Regulation by VENTX / hair follicle development / NF-kappaB binding / neuropeptide signaling pathway / positive regulation of vascular endothelial growth factor production / negative regulation by host of viral transcription / RNA polymerase II core promoter sequence-specific DNA binding / canonical NF-kappaB signal transduction / response to amino acid / positive regulation of T-helper 17 cell lineage commitment / cellular response to interleukin-1 / cellular defense response / Purinergic signaling in leishmaniasis infection / negative regulation of insulin receptor signaling pathway / response to cAMP / tumor necrosis factor-mediated signaling pathway / positive regulation of G2/M transition of mitotic cell cycle / response to muscle stretch / histone reader activity / positive regulation of interleukin-12 production / NF-kB is activated and signals survival / CD209 (DC-SIGN) signaling / negative regulation of angiogenesis / response to interleukin-1 / RNA polymerase II CTD heptapeptide repeat kinase activity / negative regulation of miRNA transcription / liver development / response to progesterone / response to organic substance / condensed nuclear chromosome / positive regulation of interleukin-1 beta production / response to cytokine / response to ischemia / positive regulation of interleukin-8 production / Dectin-1 mediated noncanonical NF-kB signaling / negative regulation of extrinsic apoptotic signaling pathway / positive regulation of transcription elongation by RNA polymerase II / Activation of NF-kappaB in B cells / transcription coregulator activity / peptide binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / animal organ morphogenesis / protein catabolic process / TAK1-dependent IKK and NF-kappa-B activation / lysine-acetylated histone binding / response to insulin / transcription coactivator binding / negative regulation of protein catabolic process / chromatin DNA binding / CLEC7A (Dectin-1) signaling / PKMTs methylate histone lysines / cellular response to hydrogen peroxide / DNA-binding transcription repressor activity, RNA polymerase II-specific / FCERI mediated NF-kB activation / positive regulation of miRNA transcription / Transcriptional regulation of white adipocyte differentiation / Interleukin-1 signaling類似検索 - 分子機能 Transcription factor RelA (p65) / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. ...Transcription factor RelA (p65) / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. / Rel homology domain (RHD), DNA-binding domain superfamily / ig-like, plexins, transcription factors / IPT domain / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / p53-like transcription factor, DNA-binding / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Immunoglobulin E-set / Immunoglobulin-like fold / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) Homo Sapiens (ヒト) |
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手法 | 溶液NMR / DGSA-distance geometry simulated annealing, torsion angle dynamics |
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データ登録者 | Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. ...Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. / Ohlmeyer, M. / He, J. / Zhou, M.-M. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2012 タイトル: Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. 著者: Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Zeng, L. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. / Ohlmeyer, M. / He, J.C. / Zhou, M.M. |
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履歴 | 登録 | 2012年5月3日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2012年7月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年8月28日 | Group: Database references |
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改定 2.0 | 2023年11月15日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations カテゴリ: atom_site / chem_comp_atom ...atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_spectrometer / struct_conn Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.model / _struct_conn.pdbx_leaving_atom_flag |
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