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- PDB-2hsp: SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA -

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Entry
Database: PDB / ID: 2hsp
TitleSOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
ComponentsPHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)
KeywordsPHOSPHORIC DIESTER HYDROLASE
Function / homology
Function and homology information


Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / PLC-gamma1 signalling / phosphoinositide phospholipase C / Role of second messengers in netrin-1 signaling / DAG and IP3 signaling / phospholipid catabolic process / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR3 ...Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / PLC-gamma1 signalling / phosphoinositide phospholipase C / Role of second messengers in netrin-1 signaling / DAG and IP3 signaling / phospholipid catabolic process / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR2 / Phospholipase C-mediated cascade; FGFR4 / phosphatidylinositol phospholipase C activity / Erythropoietin activates Phospholipase C gamma (PLCG) / COP9 signalosome / Phospholipase C-mediated cascade: FGFR1 / phospholipase C activity / neurotrophin TRKA receptor binding / positive regulation of endothelial cell apoptotic process / EGFR interacts with phospholipase C-gamma / positive regulation of vascular endothelial cell proliferation / PLCG1 events in ERBB2 signaling / Signaling by ALK / positive regulation of epithelial cell migration / Synthesis of IP3 and IP4 in the cytosol / Fc-epsilon receptor signaling pathway / phosphatidylinositol-mediated signaling / PECAM1 interactions / Generation of second messenger molecules / RET signaling / positive regulation of blood vessel endothelial cell migration / glutamate receptor binding / Role of phospholipids in phagocytosis / Signaling by FGFR4 in disease / release of sequestered calcium ion into cytosol / negative regulation of inflammatory response to antigenic stimulus / Signaling by FGFR3 in disease / cellular response to epidermal growth factor stimulus / ruffle / Signaling by FGFR2 in disease / Signaling by FGFR1 in disease / Downstream signal transduction / FCERI mediated Ca+2 mobilization / guanyl-nucleotide exchange factor activity / FCGR3A-mediated IL10 synthesis / positive regulation of release of sequestered calcium ion into cytosol / VEGFR2 mediated cell proliferation / cell projection / calcium-mediated signaling / FCERI mediated MAPK activation / Signaling by ERBB2 TMD/JMD mutants / Constitutive Signaling by EGFRvIII / Schaffer collateral - CA1 synapse / Signaling by ALK fusions and activated point mutants / modulation of chemical synaptic transmission / Signaling by ERBB2 ECD mutants / epidermal growth factor receptor signaling pathway / Signaling by ERBB2 KD Mutants / receptor tyrosine kinase binding / ISG15 antiviral mechanism / ruffle membrane / positive regulation of angiogenesis / cell-cell junction / cell migration / DAP12 signaling / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / lamellipodium / T cell receptor signaling pathway / in utero embryonic development / glutamatergic synapse / calcium ion binding / protein kinase binding / plasma membrane / cytosol / cytoplasm
Similarity search - Function
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain ...1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / Phosphatidylinositol-specific phospholipase X-box domain profile. / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / SH3 Domains / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH3 type barrels. / Src homology 3 domains / EF-Hand 1, calcium-binding site / SH2 domain superfamily / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain / EF-hand domain pair / PH-like domain superfamily / Roll / Mainly Beta
Similarity search - Domain/homology
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsKohda, D. / Hatanaka, H. / Odaka, M. / Inagaki, F.
Citation
Journal: Cell(Cambridge,Mass.) / Year: 1993
Title: Solution structure of the SH3 domain of phospholipase C-gamma.
Authors: Kohda, D. / Hatanaka, H. / Odaka, M. / Mandiyan, V. / Ullrich, A. / Schlessinger, J. / Inagaki, F.
#1: Journal: To be Published
Title: Solution Structure and Ligand-Binding Site of the C-Terminal SH3 Domain of Grb2
Authors: Kohda, D. / Terasawa, H. / Ichikawa, S. / Ogura, K. / Hatanaka, H. / Mandiyan, V. / Ullrich, A. / Schlessinger, J. / Inagaki, F.
History
DepositionJun 13, 1994Processing site: BNL
SupersessionAug 31, 1994ID: 1HSP
Revision 1.0Aug 31, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site
Revision 1.4May 1, 2024Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)


Theoretical massNumber of molelcules
Total (without water)8,2491
Polymers8,2491
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
Atom site foot note1: A BETA-BULGE STRUCTURE OCCURS AT LYS 50 - GLN 51 - LEU 52.
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / -
Representative

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Components

#1: Protein PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)


Mass: 8249.244 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: GRB2
References: UniProt: P19174, phosphoinositide phospholipase C

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameClassification
X-PLORmodel building
X-PLORrefinement
X-PLORphasing
NMR software
NameDeveloperClassification
DSPACENILGESrefinement
X-PLORBRUNGERrefinement
NMR ensembleConformers submitted total number: 20

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