- PDB-2cn7: Recombinant human H ferritin, K86Q, E27D and E107D mutant -
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データを開く
IDまたはキーワード:
読み込み中...
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基本情報
登録情報
データベース: PDB / ID: 2cn7
タイトル
Recombinant human H ferritin, K86Q, E27D and E107D mutant
要素
FERRITIN HEAVY CHAINフェリチン
キーワード
OXIDOREDUCTASE (酸化還元酵素) / IRON (鉄) / APOFERRITIN (フェリチン) / FERROXIDASE / IRON STORAGE / METAL-BINDING / PHOSPHORYLATION (リン酸化) / DI-IRON NON-HEME PROTEIN
機能・相同性
機能・相同性情報
iron ion sequestering activity / : / オートファゴソーム / Scavenging by Class A Receptors / Golgi Associated Vesicle Biogenesis / ferroxidase / ferroxidase activity / intracellular sequestering of iron ion / negative regulation of fibroblast proliferation / ferric iron binding ...iron ion sequestering activity / : / オートファゴソーム / Scavenging by Class A Receptors / Golgi Associated Vesicle Biogenesis / ferroxidase / ferroxidase activity / intracellular sequestering of iron ion / negative regulation of fibroblast proliferation / ferric iron binding / Iron uptake and transport / ferrous iron binding / tertiary granule lumen / iron ion transport / intracellular iron ion homeostasis / ficolin-1-rich granule lumen / 免疫応答 / iron ion binding / negative regulation of cell population proliferation / Neutrophil degranulation / extracellular exosome / extracellular region / 生体膜 / identical protein binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能
STORES IRON IN A SOLUBLE, NONTOXIC, READILY AVAILABLE FORM. IMPORTANT FOR IRON HOMEOSTASIS. HAS ...STORES IRON IN A SOLUBLE, NONTOXIC, READILY AVAILABLE FORM. IMPORTANT FOR IRON HOMEOSTASIS. HAS FERROXIDASE ACTIVITY. ENGINEERED RESIDUE IN CHAIN A, GLU 27 TO ASP ENGINEERED RESIDUE IN CHAIN A, LYS 86 TO GLN ENGINEERED RESIDUE IN CHAIN A, GLU 107 TO ASP
配列の詳細
MUTATION K86Q, E27D, E107D
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実験情報
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実験
実験
手法: X線回折 / 使用した結晶の数: 1
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試料調製
結晶
マシュー密度: 2.83 Å3/Da / 溶媒含有率: 56.5 %
結晶化
手法: 蒸気拡散法, ハンギングドロップ法 / pH: 8.5 詳細: HANGING DROP. RESERVOIR: MPD 5.2%, CACL2 3.9 MM, TRIS 50MM PH 8.5. DROP: 1UL PROTEIN (24 MG/ML) AND 1 UL RESERVOIR
解像度: 1.75→104.83 Å / Cor.coef. Fo:Fc: 0.958 / Cor.coef. Fo:Fc free: 0.942 / SU B: 1.8 / SU ML: 0.059 / 交差検証法: THROUGHOUT / ESU R: 0.097 / ESU R Free: 0.092 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.
Rfactor
反射数
%反射
Selection details
Rfree
0.204
1334
5.1 %
RANDOM
Rwork
0.184
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obs
0.185
24926
100 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK