Entry Database : PDB / ID : 2b5i Structure visualization Downloads & linksTitle cytokine receptor complex Components(Interleukin-2 receptor ... IL-2 receptor ) x 2 Cytokine receptor common gamma chain Interleukin-2 Interleukin 2 DetailsKeywords CYTOKINE/CYTOKINE RECEPTOR / four-helix bundle / Fibronectin domain / CYTOKINE-CYTOKINE RECEPTOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
regulation of T cell tolerance induction / interleukin-7-mediated signaling pathway / mature B cell differentiation / interleukin-2 receptor complex / interleukin-2 receptor activity / interleukin-15 receptor activity / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / kappa-type opioid receptor binding / regulation of CD4-positive, alpha-beta T cell proliferation ... regulation of T cell tolerance induction / interleukin-7-mediated signaling pathway / mature B cell differentiation / interleukin-2 receptor complex / interleukin-2 receptor activity / interleukin-15 receptor activity / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / kappa-type opioid receptor binding / regulation of CD4-positive, alpha-beta T cell proliferation / regulation of T cell homeostatic proliferation / interleukin-2 receptor binding / positive regulation of plasma cell differentiation / response to tacrolimus / glycosphingolipid binding / negative regulation of lymphocyte proliferation / activation-induced cell death of T cells / positive regulation of tissue remodeling / positive regulation of T cell differentiation in thymus / negative regulation of T-helper 17 cell differentiation / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / leukocyte activation involved in immune response / positive regulation of isotype switching to IgG isotypes / interleukin-4-mediated signaling pathway / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / interleukin-2-mediated signaling pathway / STAT3 nuclear events downstream of ALK signaling / activated T cell proliferation / positive regulation of regulatory T cell differentiation / natural killer cell activation / protein kinase C-activating G protein-coupled receptor signaling pathway / kinase activator activity / interleukin-15-mediated signaling pathway / inflammatory response to antigenic stimulus / Interleukin-15 signaling / negative regulation of B cell apoptotic process / cytokine receptor activity / Interleukin-2 signaling / positive regulation of T cell differentiation / positive regulation of B cell differentiation / positive regulation of dendritic spine development / positive regulation of activated T cell proliferation / cytokine binding / positive regulation of interleukin-17 production / positive regulation of immunoglobulin production / immunoglobulin mediated immune response / T cell differentiation / Interleukin receptor SHC signaling / coreceptor activity / positive regulation of phagocytosis / positive regulation of B cell proliferation / Notch signaling pathway / positive regulation of tyrosine phosphorylation of STAT protein / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of T cell proliferation / Interleukin-7 signaling / negative regulation of protein phosphorylation / cytokine activity / growth factor activity / negative regulation of inflammatory response / positive regulation of inflammatory response / cytokine-mediated signaling pathway / positive regulation of type II interferon production / cell-cell signaling / T cell differentiation in thymus / gene expression / positive regulation of cytosolic calcium ion concentration / RAF/MAP kinase cascade / positive regulation of cell growth / carbohydrate binding / protein-containing complex assembly / response to ethanol / Interleukin-4 and Interleukin-13 signaling / transcription by RNA polymerase II / adaptive immune response / cell surface receptor signaling pathway / receptor complex / cell adhesion / endosome / immune response / inflammatory response / external side of plasma membrane / apoptotic process / positive regulation of cell population proliferation / positive regulation of gene expression / negative regulation of apoptotic process / cell surface / endoplasmic reticulum / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / nucleoplasm / membrane / plasma membrane / cytosol Similarity search - Function Interleukin-2 receptor subunit beta, N-terminal / Interleukin-2 receptor subunit beta N-terminal domain 1 / Rubrerythrin, domain 2 - #230 / Interleukin-2 receptor alpha / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / Interleukin-2 / Interleukin-2, conserved site ... Interleukin-2 receptor subunit beta, N-terminal / Interleukin-2 receptor subunit beta N-terminal domain 1 / Rubrerythrin, domain 2 - #230 / Interleukin-2 receptor alpha / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / Interleukin-2 / Interleukin-2, conserved site / Interleukin 2 / Interleukin-2 signature. / Interleukin-2 family / Short hematopoietin receptor family 1 signature. / Interleukin-6 receptor alpha chain, binding / Short hematopoietin receptor, family 1, conserved site / Complement Module, domain 1 / Complement Module; domain 1 / Growth Hormone; Chain: A; - #10 / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Rubrerythrin, domain 2 / Single Sheet / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Ribbon / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homology Interleukin-2 receptor subunit alpha / Interleukin-2 receptor subunit beta / Cytokine receptor common subunit gamma / Interleukin-2 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Wang, X. / Rickert, M. / Garcia, K.C. CitationJournal : Science / Year : 2005Title : Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.Authors : Wang, X. / Rickert, M. / Garcia, K.C. History Deposition Sep 28, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 29, 2005 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Version format complianceRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Oct 20, 2021 Group : Database references / Structure summary / Category : chem_comp / database_2 / struct_ref_seq_difItem : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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