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- PDB-1uom: The Structure of Estrogen Receptor in Complex with a Selective an... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1uom | ||||||
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Title | The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand. | ||||||
![]() | ESTROGEN RECEPTOR![]() | ||||||
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Function / homology | ![]() regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Stark, W. / Bischoff, S.F. / Buhl, T. / Fournier, B. / Halleux, C. / Kallen, J. / Keller, H. / Renaud, J. | ||||||
![]() | ![]() Title: Estrogen Receptor Modulators: Identification and Structure-Activity Relationships of Potent Eralpha-Selective Tetrahydroisoquinoline Ligands Authors: Renaud, J. / Bischoff, S.F. / Buhl, T. / Floersheim, P. / Fournier, B. / Halleux, C. / Kallen, J. / Keller, H. / Schlaeppi, J.-M. / Stark, W. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 64 KB | Display | ![]() |
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PDB format | ![]() | 46.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 3ertS S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 28972.021 Da / Num. of mol.: 1 / Fragment: LIGAND BINDING DOMAIN, RESIDUES 301 - 553 / Mutation: YES Source method: isolated from a genetically manipulated source Details: NVP-ADD562 L SOLVENT S / Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() |
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#2: Chemical | ChemComp-PTI / |
#3: Water | ChemComp-HOH / ![]() |
Compound details | FUNCTION: NUCLEAR HORMONE RECEPTOR. THE STEROID HORMONES AND RECEPTORS AFFECT CELLULAR ...FUNCTION: NUCLEAR HORMONE RECEPTOR. THE STEROID HORMONES AND RECEPTORS AFFECT CELLULAR PROLIFERAT |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.3 Å3/Da / Density % sol: 43 % | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Crystal grow![]() | pH: 6.5 / Details: 0.1 M MES PH 6.5 9-11% PEG-3350, 0.4 M NACL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Crystal grow | *PLUS pH: 8 / Method: vapor diffusion, hanging drop | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: MARRESEARCH / Detector: IMAGE PLATE / Date: Jan 25, 2001 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.28→10 Å / Num. obs: 10439 / % possible obs: 77.8 % / Redundancy: 5.5 % / Biso Wilson estimate: 32.9 Å2 / Rmerge(I) obs: 0.053 / Net I/σ(I): 17.5 |
Reflection shell | Resolution: 2.28→2.32 Å / Redundancy: 17.5 % / Rmerge(I) obs: 0.23 / Mean I/σ(I) obs: 10.7 / % possible all: 68.8 |
Reflection | *PLUS Highest resolution: 2.28 Å / Rmerge(I) obs: 0.053 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: PDB ENTRY 3ERT Resolution: 2.28→9.99 Å / Rfactor Rfree error: 0.009 / Cross valid method: THROUGHOUT / σ(F): 0
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Solvent computation | Solvent model: FLAT MODEL / Bsol: 46.02 Å2 / ksol: 0.377 e/Å3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 40.2 Å2
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Refine analyze |
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Refinement step | Cycle: LAST / Resolution: 2.28→9.99 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.28→2.42 Å / Rfactor Rfree error: 0.029 / Total num. of bins used: 6
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Xplor file |
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Refinement | *PLUS Rfactor Rwork![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS
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