Entry Database : PDB / ID : 1ud0 Structure visualization Downloads & linksTitle CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70 Components70 kDa heat-shock-like protein Details Keywords CHAPERONE / HSC70Function / homology Function and homology informationFunction Domain/homology Component
Attenuation phase / PKR-mediated signaling / positive regulation of protein refolding / prostaglandin binding / positive regulation of lysosomal membrane permeability / lysosomal matrix / Protein methylation / A1 adenosine receptor binding / HSF1-dependent transactivation / mRNA Splicing - Major Pathway ... Attenuation phase / PKR-mediated signaling / positive regulation of protein refolding / prostaglandin binding / positive regulation of lysosomal membrane permeability / lysosomal matrix / Protein methylation / A1 adenosine receptor binding / HSF1-dependent transactivation / mRNA Splicing - Major Pathway / AUF1 (hnRNP D0) binds and destabilizes mRNA / response to nickel cation / protein transmembrane import into intracellular organelle / negative regulation of supramolecular fiber organization / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / response to odorant / Lysosome Vesicle Biogenesis / positive regulation by host of viral genome replication / synaptic vesicle uncoating / protein-containing complex disassembly / GABA synthesis, release, reuptake and degradation / Golgi Associated Vesicle Biogenesis / chaperone-mediated autophagy translocation complex disassembly / slow axonal transport / clathrin-uncoating ATPase activity / Regulation of HSF1-mediated heat shock response / protein targeting to lysosome involved in chaperone-mediated autophagy / messenger ribonucleoprotein complex / late endosomal microautophagy / modulation by host of viral process / C3HC4-type RING finger domain binding / negative regulation of NLRP3 inflammasome complex assembly / clathrin coat disassembly / photoreceptor ribbon synapse / maintenance of postsynaptic specialization structure / ATP-dependent protein disaggregase activity / regulation of protein complex stability / Clathrin-mediated endocytosis / glycinergic synapse / neuron spine / Prp19 complex / postsynaptic specialization membrane / presynaptic cytosol / positive regulation of mRNA splicing, via spliceosome / axo-dendritic transport / protein folding chaperone complex / regulation of postsynapse organization / intermediate filament / negative regulation of cardiac muscle cell apoptotic process / postsynaptic cytosol / Neutrophil degranulation / chaperone-mediated autophagy / phosphatidylserine binding / response to starvation / non-chaperonin molecular chaperone ATPase / positive regulation of proteolysis / chaperone cofactor-dependent protein refolding / estrous cycle / asymmetric synapse / autophagosome / positive regulation of phagocytosis / chaperone-mediated protein folding / ATP metabolic process / protein folding chaperone / forebrain development / skeletal muscle tissue development / cellular response to cadmium ion / heat shock protein binding / photoreceptor inner segment / cerebellum development / lysosomal lumen / RNA splicing / dendritic shaft / response to activity / response to progesterone / kidney development / G protein-coupled receptor binding / ADP binding / ATP-dependent protein folding chaperone / peptide binding / G1/S transition of mitotic cell cycle / spliceosomal complex / regulation of protein stability / terminal bouton / mRNA processing / cellular response to hydrogen peroxide / positive regulation of T cell mediated cytotoxicity / protein import into nucleus / unfolded protein binding / melanosome / protein-macromolecule adaptor activity / synaptic vesicle / late endosome / protein folding / presynapse / response to estradiol / cellular response to heat / protein-folding chaperone binding / perikaryon / protein refolding Similarity search - Function Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #10 / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ... Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #10 / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 / ATPase, nucleotide binding domain / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 3.45 Å DetailsAuthors Chou, C.C. / Forouhar, F. / Yeh, Y.H. / Wang, C. / Hsiao, C.D. CitationJournal : J.BIOL.CHEM. / Year : 2003Title : Crystal structure of the C-terminal 10-kDa subdomain of Hsc70Authors : Chou, C.C. / Forouhar, F. / Yeh, Y.H. / Shr, H.L. / Wang, C. / Hsiao, C.D. History Deposition Apr 24, 2003 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 May 11, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 27, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Nov 16, 2011 Group : Atomic modelRevision 1.4 Dec 27, 2023 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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