+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1rml | ||||||
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タイトル | NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES | ||||||
要素 | ACIDIC FIBROBLAST GROWTH FACTORFGF1 | ||||||
キーワード | GROWTH FACTOR (成長因子) / FIBROBLAST GROWTH FACTOR (線維芽細胞増殖因子) / ANTITUMORAL / NAPHTHALENE (ナフタレン) | ||||||
機能・相同性 | 機能・相同性情報 mesonephric epithelium development / branch elongation involved in ureteric bud branching / regulation of endothelial tube morphogenesis / FGFR3b ligand binding and activation / regulation of endothelial cell chemotaxis to fibroblast growth factor / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / FGFR2b ligand binding and activation / positive regulation of cholesterol biosynthetic process ...mesonephric epithelium development / branch elongation involved in ureteric bud branching / regulation of endothelial tube morphogenesis / FGFR3b ligand binding and activation / regulation of endothelial cell chemotaxis to fibroblast growth factor / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / FGFR2b ligand binding and activation / positive regulation of cholesterol biosynthetic process / fibroblast growth factor receptor binding / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / Phospholipase C-mediated cascade; FGFR2 / FGFR4 ligand binding and activation / FGFR1b ligand binding and activation / Phospholipase C-mediated cascade; FGFR4 / Signaling by activated point mutants of FGFR1 / FGFR1c ligand binding and activation / organ induction / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / positive regulation of hepatocyte proliferation / S100 protein binding / positive regulation of intracellular signal transduction / Signaling by FGFR2 IIIa TM / PI-3K cascade:FGFR3 / positive regulation of sprouting angiogenesis / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR4 / PI-3K cascade:FGFR1 / positive regulation of cell division / PI3K Cascade / anatomical structure morphogenesis / fibroblast growth factor receptor signaling pathway / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR3 signaling / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / Hsp70 protein binding / Signaling by FGFR2 in disease / Signaling by FGFR1 in disease / activation of protein kinase B activity / positive regulation of endothelial cell migration / 細胞外マトリックス / epithelial cell proliferation / positive regulation of epithelial cell proliferation / Negative regulation of FGFR3 signaling / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / Negative regulation of FGFR1 signaling / animal organ morphogenesis / growth factor activity / positive regulation of MAP kinase activity / lung development / wound healing / positive regulation of angiogenesis / Constitutive Signaling by Aberrant PI3K in Cancer / integrin binding / PIP3 activates AKT signaling / heparin binding / cellular response to heat / 細胞皮質 / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / 血管新生 / positive regulation of ERK1 and ERK2 cascade / 細胞分化 / positive regulation of cell migration / positive regulation of cell population proliferation / positive regulation of gene expression / シグナル伝達 / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / 核質 / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR / VARIABLE TARGET FUNCTION | ||||||
データ登録者 | Lozano, R.M. / Jimenez, M.A. / Santoro, J. / Rico, M. / Gimenez-Gallego, G. | ||||||
引用 | ジャーナル: J.Mol.Biol. / 年: 1998 タイトル: Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas. 著者: Lozano, R.M. / Jimenez, M. / Santoro, J. / Rico, M. / Gimenez-Gallego, G. #1: ジャーナル: J.Mol.Biol. / 年: 1996 タイトル: Three-Dimensional Structure of Acidic Fibroblast Growth Factor in Solution: Effects of Binding to a Heparin Functional Analog 著者: Pineda-Lucena, A. / Jimenez, M.A. / Lozano, R.M. / Nieto, J.L. / Santoro, J. / Rico, M. / Gimenez-Gallego, G. #2: ジャーナル: J.Mol.Biol. / 年: 1994 タイトル: 1H-NMR Assignment and Solution Structure of Human Acidic Fibroblast Growth Factor Activated by Inositol Hexasulfate 著者: Pineda-Lucena, A. / Jimenez, M.A. / Nieto, J.L. / Santoro, J. / Rico, M. / Gimenez-Gallego, G. #3: ジャーナル: J.Mol.Biol. / 年: 1994 タイトル: Erratum. 1H-NMR Assignment and Solution Structure of Human Acidic Fibroblast Growth Factor Activated by Inositol Hexasulfate 著者: Pineda-Lucena, A. / Jimenez, M.A. / Nieto, J.L. / Santoro, J. / Rico, M. / Gimenez-Gallego, G. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1rml.cif.gz | 1 MB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1rml.ent.gz | 879.8 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1rml.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/rm/1rml ftp://data.pdbj.org/pub/pdb/validation_reports/rm/1rml | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 17482.697 Da / 分子数: 1 / 断片: RESIDUES 23 - 154 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / プラスミド: PMG47 / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P05230 |
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#2: 化合物 | ChemComp-NTS / |
-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||
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NMR実験 |
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-試料調製
詳細 | 内容: WATER |
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試料状態 | pH: 6.0 / 温度: 298 K |
結晶化 | *PLUS 手法: その他 / 詳細: NMR |
-NMR測定
NMRスペクトロメーター | タイプ: Bruker AMX 600 / 製造業者: Bruker / モデル: AMX 600 / 磁場強度: 600 MHz |
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-解析
NMR software |
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精密化 | 手法: VARIABLE TARGET FUNCTION / ソフトェア番号: 1 | |||||||||
NMRアンサンブル | 計算したコンフォーマーの数: 26 / 登録したコンフォーマーの数: 26 |