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Yorodumi- PDB-1nlp: STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1nlp | |||||||||
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Title | STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE | |||||||||
Components |
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Keywords | COMPLEX (TRANSFERASE/PEPTIDE) / SRC / SH3 DOMAIN / LIGANDS / NON-PEPTIDE ELEMENTS / COMPLEX (TRANSFERASE-PEPTIDE) / COMPLEX (TRANSFERASE-PEPTIDE) complex | |||||||||
Function / homology | Function and homology information Signaling by ERBB2 / Nuclear signaling by ERBB4 / PIP3 activates AKT signaling / Signaling by SCF-KIT / Regulation of KIT signaling / Signaling by EGFR / GAB1 signalosome / Regulation of gap junction activity / FCGR activation / PECAM1 interactions ...Signaling by ERBB2 / Nuclear signaling by ERBB4 / PIP3 activates AKT signaling / Signaling by SCF-KIT / Regulation of KIT signaling / Signaling by EGFR / GAB1 signalosome / Regulation of gap junction activity / FCGR activation / PECAM1 interactions / CD28 co-stimulation / CTLA4 inhibitory signaling / EPHA-mediated growth cone collapse / Ephrin signaling / G alpha (i) signalling events / GP1b-IX-V activation signalling / Recycling pathway of L1 / Thrombin signalling through proteinase activated receptors (PARs) / VEGFR2 mediated cell proliferation / RAF activation / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RET signaling / Receptor Mediated Mitophagy / ADP signalling through P2Y purinoceptor 1 / Downregulation of ERBB4 signaling / EPH-ephrin mediated repulsion of cells / Cyclin D associated events in G1 / Regulation of RUNX3 expression and activity / Activated NTRK3 signals through PI3K / Downstream signal transduction / MAP2K and MAPK activation / Integrin signaling / GRB2:SOS provides linkage to MAPK signaling for Integrins / MET activates PTK2 signaling / Extra-nuclear estrogen signaling / EPHB-mediated forward signaling / p130Cas linkage to MAPK signaling for integrins / VEGFA-VEGFR2 Pathway / connexin binding / osteoclast development / progesterone receptor signaling pathway / negative regulation of intrinsic apoptotic signaling pathway / bone resorption / extrinsic component of cytoplasmic side of plasma membrane / negative regulation of extrinsic apoptotic signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / epidermal growth factor receptor signaling pathway / cell junction / protein phosphatase binding / protein tyrosine kinase activity / mitochondrial inner membrane / cell differentiation / cytoskeleton / endosome membrane / regulation of cell cycle / cell adhesion / cell cycle / phosphorylation / signaling receptor binding / focal adhesion / innate immune response / heme binding / perinuclear region of cytoplasm / protein-containing complex / ATP binding / membrane / nucleus / plasma membrane / cytosol Similarity search - Function | |||||||||
Biological species | Gallus gallus (chicken) | |||||||||
Method | SOLUTION NMR | |||||||||
Authors | Feng, S. / Kapoor, T.M. / Shirai, F. / Combs, A.P. / Schreiber, S.L. | |||||||||
Citation | Journal: Chem.Biol. / Year: 1996 Title: Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Authors: Feng, S. / Kapoor, T.M. / Shirai, F. / Combs, A.P. / Schreiber, S.L. #1: Journal: J.Am.Chem.Soc. / Year: 1996 Title: Protein Structure-Based Combinatorial Chemistry: Discovery of Non-Peptide Binding Elements to Src SH3 Domain Authors: Combs, A.P. / Kapoor, T.M. / Feng, S. / Chen, J.K. / Daude-Snow, L.F. / Schreiber, S.L. #2: Journal: Proc.Natl.Acad.Sci.USA / Year: 1995 Title: Specific Interactions Outside the Proline-Rich Core of Two Classes of Src Homology 3 Ligands Authors: Feng, S. / Kasahara, C. / Rickles, R.J. / Schreiber, S.L. #3: Journal: Cell(Cambridge,Mass.) / Year: 1994 Title: Structural Basis for the Binding of Proline-Rich Peptides to SH3 Domains Authors: Yu, H. / Chen, J.K. / Feng, S. / Dalgarno, D.C. / Brauer, A.W. / Schreiber, S.L. #4: Journal: Science / Year: 1994 Title: Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions Authors: Feng, S. / Chen, J.K. / Yu, H. / Simon, J.A. / Schreiber, S.L. #5: Journal: Science / Year: 1992 Title: Solution Structure of the SH3 Domain of Src and Identification of its Ligand-Binding Site Authors: Yu, H. / Rosen, M.K. / Shin, T.B. / Seidel-Dugan, C. / Brugge, J.S. / Schreiber, S.L. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1nlp.cif.gz | 35.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1nlp.ent.gz | 23.2 KB | Display | PDB format |
PDBx/mmJSON format | 1nlp.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/nl/1nlp ftp://data.pdbj.org/pub/pdb/validation_reports/nl/1nlp | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 7104.749 Da / Num. of mol.: 1 / Fragment: SH3 DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) Gallus gallus (chicken) / Gene: CHICKEN / Plasmid: PGEX-2T / Gene (production host): CHICKEN / Production host: GST-FUSION References: UniProt: P00525, UniProt: P00523*PLUS, EC: 2.7.1.112 |
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#2: Protein/peptide | Mass: 1052.353 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: LIGAND NL2 CONTAINS NON-PEPTIDE ELEMENTS |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformer selection criteria: MINIMIZED AVERAGE / Conformers submitted total number: 1 |