- PDB-1lqv: Crystal structure of the Endothelial protein C receptor with phos... -
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Basic information
Entry
Database: PDB / ID: 1lqv
Title
Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C.
Components
Endothelial protein C receptor
Vitamin-K dependent protein C
Keywords
BLOOD CLOTTING / Gla (gamma-carboxyglutamic acid) residues / phospholipid binding groove / Ca ion binding
Function / homology
Function and homology information
protein C (activated) / positive regulation of establishment of endothelial barrier / negative regulation of coagulation / negative regulation of blood coagulation / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Intrinsic Pathway of Fibrin Clot Formation / Cell surface interactions at the vascular wall ...protein C (activated) / positive regulation of establishment of endothelial barrier / negative regulation of coagulation / negative regulation of blood coagulation / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Intrinsic Pathway of Fibrin Clot Formation / Cell surface interactions at the vascular wall / Post-translational protein phosphorylation / negative regulation of inflammatory response / Golgi lumen / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / blood coagulation / signaling receptor activity / endoplasmic reticulum lumen / serine-type endopeptidase activity / focal adhesion / centrosome / calcium ion binding / negative regulation of apoptotic process / perinuclear region of cytoplasm / Golgi apparatus / cell surface / endoplasmic reticulum / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function
Endothelial protein C receptor / MHC-I family domain / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Coagulation Factor Xa inhibitory site / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain ...Endothelial protein C receptor / MHC-I family domain / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Coagulation Factor Xa inhibitory site / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Epidermal growth factor-like domain. / EGF-like domain profile. / MHC class I-like antigen recognition-like / Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
PHOSPHATIDYLETHANOLAMINE / Vitamin K-dependent protein C / Endothelial protein C receptor Similarity search - Component
Biological species
Homo sapiens (human)
Method
X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 1.6 Å
EndothelialproteinCreceptor / / Endothelial cell protein C receptor / Activated protein C receptor / APC receptor
Mass: 22046.562 Da / Num. of mol.: 2 / Fragment: Extracellular domain Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Plasmid: pEE EPCR / Production host: Cricetulus griseus (Chinese hamster) / Strain (production host): CHO lecI / References: UniProt: Q9UNN8
#2: Protein/peptide
Vitamin-KdependentproteinC / Autoprothrombin IIA / Anticoagulant protein C / Blood coagulation factor XIV
Mass: 4359.409 Da / Num. of mol.: 2 / Fragment: Protein C Gla domain Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) Description: Cleavage happened during crystallization and the crystal contains only the N-terminal domain (Gla domain) of protein C. References: UniProt: P04070
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