+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1kla | ||||||
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タイトル | SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 1-17 OF 33 STRUCTURES | ||||||
要素 | TRANSFORMING GROWTH FACTOR-BETA 1TGF-β | ||||||
キーワード | GROWTH FACTOR (成長因子) / MITOGEN (分裂促進因子) / GLYCOPROTEIN (糖タンパク質) | ||||||
機能・相同性 | 機能・相同性情報 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / Influenza Virus Induced Apoptosis / regulation of branching involved in mammary gland duct morphogenesis / frontal suture morphogenesis / negative regulation of skeletal muscle tissue development / TGFBR2 MSI Frameshift Mutants in Cancer / regulation of enamel mineralization ...adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / Influenza Virus Induced Apoptosis / regulation of branching involved in mammary gland duct morphogenesis / frontal suture morphogenesis / negative regulation of skeletal muscle tissue development / TGFBR2 MSI Frameshift Mutants in Cancer / regulation of enamel mineralization / regulatory T cell differentiation / regulation of cartilage development / regulation of blood vessel remodeling / regulation of striated muscle tissue development / tolerance induction to self antigen / negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / regulation of protein import into nucleus / extracellular matrix assembly / embryonic liver development / columnar/cuboidal epithelial cell maturation / type III transforming growth factor beta receptor binding / negative regulation of hyaluronan biosynthetic process / Langerhans cell differentiation / positive regulation of odontogenesis / positive regulation of cardiac muscle cell differentiation / myofibroblast differentiation / connective tissue replacement involved in inflammatory response wound healing / positive regulation of exit from mitosis / negative regulation of macrophage cytokine production / positive regulation of receptor signaling pathway via STAT / odontoblast differentiation / TGFBR2 Kinase Domain Mutants in Cancer / positive regulation of smooth muscle cell differentiation / positive regulation of mesenchymal stem cell proliferation / positive regulation of isotype switching to IgA isotypes / positive regulation of primary miRNA processing / mammary gland branching involved in thelarche / membrane protein intracellular domain proteolysis / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / heart valve morphogenesis / response to laminar fluid shear stress / retina vasculature development in camera-type eye / positive regulation of vasculature development / hyaluronan catabolic process / bronchiole development / regulation of transforming growth factor beta receptor signaling pathway / ATP biosynthetic process / receptor catabolic process / positive regulation of branching involved in ureteric bud morphogenesis / negative regulation of extracellular matrix disassembly / positive regulation of extracellular matrix assembly / lens fiber cell differentiation / response to salt / type II transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / oligodendrocyte development / germ cell migration / negative regulation of biomineral tissue development / type I transforming growth factor beta receptor binding / positive regulation of chemotaxis / phospholipid homeostasis / endoderm development / negative regulation of myoblast differentiation / positive regulation of mononuclear cell migration / cell-cell junction organization / response to vitamin D / positive regulation of vascular permeability / positive regulation of regulatory T cell differentiation / response to cholesterol / deubiquitinase activator activity / digestive tract development / positive regulation of endothelial cell apoptotic process / negative regulation of interleukin-17 production / surfactant homeostasis / negative regulation of release of sequestered calcium ion into cytosol / positive regulation of fibroblast migration / negative regulation of ossification / positive regulation of chemokine (C-X-C motif) ligand 2 production / aortic valve morphogenesis / phosphate-containing compound metabolic process / negative regulation of phagocytosis / negative regulation of protein localization to plasma membrane / 血管新生 / neural tube development / face morphogenesis / Molecules associated with elastic fibres / RUNX3 regulates CDKN1A transcription / ureteric bud development / ventricular cardiac muscle tissue morphogenesis / cellular response to insulin-like growth factor stimulus / positive regulation of epidermal growth factor receptor signaling pathway / negative regulation of neuroblast proliferation / macrophage derived foam cell differentiation / Syndecan interactions / muscle cell cellular homeostasis / negative regulation of cell-cell adhesion / negative regulation of fat cell differentiation / lung alveolus development / positive regulation of interleukin-17 production 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Hinck, A.P. / Archer, S.J. / Qian, S.W. / Roberts, A.B. / Sporn, M.B. / Weatherbee, J.A. / Tsang, M.L.-S. / Lucas, R. / Zhang, B.-L. / Wenker, J. / Torchia, D.A. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1996 タイトル: Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. 著者: Hinck, A.P. / Archer, S.J. / Qian, S.W. / Roberts, A.B. / Sporn, M.B. / Weatherbee, J.A. / Tsang, M.L. / Lucas, R. / Zhang, B.L. / Wenker, J. / Torchia, D.A. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1kla.cif.gz | 1.1 MB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1kla.ent.gz | 1008.2 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1kla.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/kl/1kla ftp://data.pdbj.org/pub/pdb/validation_reports/kl/1kla | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 12809.812 Da / 分子数: 2 / 由来タイプ: 組換発現 / 詳細: 1 MM (IN DIMER), PH 4.2 / 由来: (組換発現) Homo sapiens (ヒト) / 器官: OVARY 発現宿主: Cricetulus griseus (モンゴルキヌゲネズミ) 参照: UniProt: P01137 |
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-実験情報
-実験
実験 | 手法: 溶液NMR |
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NMR実験の詳細 | Text: THIS ENTRY CONTAINS 1 - 17 OF 33 MODELS. 1 MM (IN DIMER). |
-試料調製
試料状態 | pH: 4.2 / Temperature units: K |
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結晶化 | *PLUS 手法: その他 / 詳細: NMR |
-解析
ソフトウェア |
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NMR software |
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NMRアンサンブル | 計算したコンフォーマーの数: 33 / 登録したコンフォーマーの数: 17 |