- PDB-1jk8: Crystal structure of a human insulin peptide-HLA-DQ8 complex -
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Basic information
Entry
Database: PDB / ID: 1jk8
Title
Crystal structure of a human insulin peptide-HLA-DQ8 complex
Components
(MHC class II HLA-DQ8) x 2
insulin B peptide
Keywords
IMMUNE SYSTEM / HLA-DQ8 / insulin B peptide / type 1 diabetes / autoimmunity
Function / homology
Function and homology information
: / MHC class II receptor activity / transport vesicle membrane / negative regulation of NAD(P)H oxidase activity / negative regulation of glycogen catabolic process / regulation of cellular amino acid metabolic process / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / Signaling by Insulin receptor / nitric oxide-cGMP-mediated signaling ...: / MHC class II receptor activity / transport vesicle membrane / negative regulation of NAD(P)H oxidase activity / negative regulation of glycogen catabolic process / regulation of cellular amino acid metabolic process / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / Signaling by Insulin receptor / nitric oxide-cGMP-mediated signaling / IRS activation / Insulin processing / regulation of protein secretion / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / positive regulation of peptide hormone secretion / positive regulation of respiratory burst / plasma membrane => GO:0005886 / Regulation of gene expression in beta cells / negative regulation of acute inflammatory response / alpha-beta T cell activation / humoral immune response / negative regulation of respiratory burst involved in inflammatory response / Generation of second messenger molecules / positive regulation of dendritic spine maintenance / positive regulation of glycogen biosynthetic process / PD-1 signaling / Synthesis, secretion, and deacylation of Ghrelin / negative regulation of protein secretion / positive regulation of nitric oxide mediated signal transduction / fatty acid homeostasis / regulation of protein localization to plasma membrane / Signal attenuation / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / negative regulation of lipid catabolic process / negative regulation of gluconeogenesis / COPI-mediated anterograde transport / type II interferon-mediated signaling pathway / positive regulation of lipid biosynthetic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / negative regulation of reactive oxygen species biosynthetic process / positive regulation of insulin receptor signaling pathway / transport vesicle / positive regulation of protein autophosphorylation / Insulin receptor recycling / insulin-like growth factor receptor binding / neuron projection maintenance / MHC class II antigen presentation / NPAS4 regulates expression of target genes / positive regulation of protein metabolic process / positive regulation of brown fat cell differentiation / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of glycolytic process / activation of protein kinase B activity / positive regulation of mitotic nuclear division / Insulin receptor signalling cascade / trans-Golgi network membrane / positive regulation of cytokine production / positive regulation of long-term synaptic potentiation / Regulation of insulin secretion / acute-phase response / endosome lumen / positive regulation of protein secretion / positive regulation of glucose import / positive regulation of nitric-oxide synthase activity / lumenal side of endoplasmic reticulum membrane / positive regulation of cell differentiation / negative regulation of proteolysis / regulation of transmembrane transporter activity / clathrin-coated endocytic vesicle membrane / wound healing / regulation of synaptic plasticity / insulin receptor binding / ER to Golgi transport vesicle membrane / negative regulation of protein catabolic process / hormone activity / cognition / positive regulation of neuron projection development / peptide antigen assembly with MHC class II protein complex / Golgi lumen / MHC class II protein complex / positive regulation of protein localization to nucleus / vasodilation / peptide antigen binding / endocytic vesicle membrane / glucose metabolic process / antigen processing and presentation of exogenous peptide antigen via MHC class II / regulation of protein localization / Interferon gamma signaling / positive regulation of immune response / positive regulation of T cell activation / Downstream TCR signaling / insulin receptor signaling pathway / cell-cell signaling / MHC class II protein complex binding / glucose homeostasis / late endosome membrane / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Similarity search - Function
Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / Insulin ...Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / Insulin / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Roll / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homology
: / Insulin / HLA class II histocompatibility antigen, DQ alpha 1 chain / HLA class II histocompatibility antigen, DQ beta 1 chain / HLA class II histocompatibility antigen, DQ alpha 1 chain Similarity search - Component
Mass: 20734.102 Da / Num. of mol.: 1 / Fragment: alpha chain (DQA1*0301) Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P04225, UniProt: P01909*PLUS
#2: Protein
MHCclassIIHLA-DQ8
Mass: 22333.100 Da / Num. of mol.: 1 / Fragment: beta chain (DQB1*0302) Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P01920
#3: Protein/peptide
insulinBpeptide
Mass: 1479.721 Da / Num. of mol.: 1 / Fragment: peptide (9-SHLVEALYLVCGERG-23) / Source method: obtained synthetically Details: THIS PEPTIDE WAS CHEMICALLY SYNTHESIZED. THE SEQUENCE OF THIS PEPTIDE OCCURS NATURALLY IN HUMANS (HOMO SAPIENS). References: GenBank: 3776078, UniProt: P01308*PLUS
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