- PDB-1j3s: Solution Structure of Reduced Recombinant Human Cytochrome c -
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基本情報
登録情報
データベース: PDB / ID: 1j3s
タイトル
Solution Structure of Reduced Recombinant Human Cytochrome c
要素
Cytochrome cシトクロムc
キーワード
ELECTRON TRANSPORT (電子伝達系) / Ferrocytochrome c
機能・相同性
機能・相同性情報
Formation of apoptosome / アポトソーム / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Release of apoptotic factors from the mitochondria / Respiratory electron transport / Regulation of the apoptosome activity / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / 細胞呼吸 ...Formation of apoptosome / アポトソーム / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Release of apoptotic factors from the mitochondria / Respiratory electron transport / Regulation of the apoptosome activity / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / 細胞呼吸 / mitochondrial electron transport, cytochrome c to oxygen / mitochondrial electron transport, ubiquinol to cytochrome c / Detoxification of Reactive Oxygen Species / respirasome / Pyroptosis / intrinsic apoptotic signaling pathway / TP53 Regulates Metabolic Genes / Transcriptional activation of mitochondrial biogenesis / ミトコンドリア / Cytoprotection by HMOX1 / ミトコンドリア内膜 / electron transfer activity / heme binding / ミトコンドリア / metal ion binding / 細胞核 / 細胞質基質 類似検索 - 分子機能
2mM Cytochrome c U-15N, 13C; 25mM phosphate buffer
90% H2O/10% D2O
6
2mM Cytochrome c U-15N, 13C; 25mM phosphate buffer
100% D2O
試料状態
イオン強度: 125 / pH: 6.5 / 圧: ambient / 温度: 300 K
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NMR測定
放射
プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M
放射波長
相対比: 1
NMRスペクトロメーター
タイプ: Bruker AVANCE / 製造業者: Bruker / モデル: AVANCE / 磁場強度: 600 MHz
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解析
NMR software
名称
バージョン
開発者
分類
X-PLOR
3.85
Brunger
精密化
AURELIA
2.5.9
Neidig
データ解析
XwinNMR
2.6
Bruker
解析
精密化
手法: Hybrid distance geometry-dynamical simulated annealing method ソフトェア番号: 1 詳細: The structures are based on a total of 1562 restraints, 1449 are NOE-derived distance constraints, 80 dihedral angle restraints,33 distance restraints from hydrogen bonds.