登録情報 | データベース: PDB / ID: 1i3o |
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タイトル | CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3 |
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要素 | - (CASPASE 3
カスパーゼ-3) x 2 - BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4
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キーワード | APOPTOSIS (アポトーシス) / complex / IAP / caspase (カスパーゼ) |
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機能・相同性 | 機能・相同性情報
endopeptidase regulator activity / regulation of apoptosis involved in tissue homeostasis / inhibition of cysteine-type endopeptidase activity / positive regulation of protein linear polyubiquitination / regulation of BMP signaling pathway / copper ion homeostasis / nucleotide-binding oligomerization domain containing 1 signaling pathway / regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 ...endopeptidase regulator activity / regulation of apoptosis involved in tissue homeostasis / inhibition of cysteine-type endopeptidase activity / positive regulation of protein linear polyubiquitination / regulation of BMP signaling pathway / copper ion homeostasis / nucleotide-binding oligomerization domain containing 1 signaling pathway / regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis / response to cobalt ion / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / death-inducing signaling complex / cyclin-dependent protein serine/threonine kinase inhibitor activity / cellular response to staurosporine / Apoptosis induced DNA fragmentation / nucleotide-binding oligomerization domain containing 2 signaling pathway / cysteine-type endopeptidase activity involved in execution phase of apoptosis / Caspase activation via Dependence Receptors in the absence of ligand / Apoptotic cleavage of cell adhesion proteins / death receptor binding / SMAC, XIAP-regulated apoptotic response / Regulation of the apoptosome activity / axonal fasciculation / Activation of caspases through apoptosome-mediated cleavage / Signaling by Hippo / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cysteine-type endopeptidase activity involved in apoptotic process / TNFR1-induced proapoptotic signaling / fibroblast apoptotic process / execution phase of apoptosis / negative regulation of cytokine production / epithelial cell apoptotic process / platelet formation / RIPK1-mediated regulated necrosis / cysteine-type endopeptidase inhibitor activity / Other interleukin signaling / positive regulation of amyloid-beta formation / protein serine/threonine kinase binding / regulation of innate immune response / Apoptotic cleavage of cellular proteins / negative regulation of B cell proliferation / pyroptotic inflammatory response / T cell homeostasis / negative regulation of activated T cell proliferation / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / protein K63-linked ubiquitination / neurotrophin TRK receptor signaling pathway / B cell homeostasis / protein maturation / negative regulation of cell cycle / response to X-ray / negative regulation of tumor necrosis factor-mediated signaling pathway / positive regulation of type I interferon production / regulation of macroautophagy / Caspase-mediated cleavage of cytoskeletal proteins / 細胞分化 / response to amino acid / Pyroptosis / response to tumor necrosis factor / enzyme activator activity / response to glucose / response to UV / response to glucocorticoid / keratinocyte differentiation / striated muscle cell differentiation / Degradation of the extracellular matrix / Regulation of PTEN localization / intrinsic apoptotic signaling pathway / 赤血球形成 / TNFR1-induced NF-kappa-B signaling pathway / positive regulation of protein ubiquitination / Deactivation of the beta-catenin transactivating complex / hippocampus development / apoptotic signaling pathway / Regulation of TNFR1 signaling / sensory perception of sound / positive regulation of JNK cascade / response to nicotine / RING-type E3 ubiquitin transferase / protein catabolic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / regulation of protein stability / neuron differentiation / response to hydrogen peroxide / Regulation of necroptotic cell death / protein processing / Wntシグナル経路 / response to wounding / Regulation of PTEN stability and activity / ubiquitin-protein transferase activity類似検索 - 分子機能 XIAP/BIRC8, UBA domain / : / BIRC2/3-like, UBA domain / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Caspase-like / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. ...XIAP/BIRC8, UBA domain / : / BIRC2/3-like, UBA domain / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Caspase-like / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. / Baculoviral inhibition of apoptosis protein repeat / Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Zinc finger, C3HC4 type (RING finger) / Caspase-like domain superfamily / Death-like domain superfamily / 薬指 / Zinc finger RING-type profile. / Zinc finger, RING-type / Alpha-Beta Plaits / ロスマンフォールド / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.7 Å |
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データ登録者 | Riedl, S.J. / Renatus, M. / Schwarzenbacher, R. / Zhou, Q. / Sun, C. / Fesik, S.W. / Liddington, R.C. / Salvesen, G.S. |
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引用 | ジャーナル: Cell(Cambridge,Mass.) / 年: 2001 タイトル: Structural basis for the inhibition of caspase-3 by XIAP. 著者: Riedl, S.J. / Renatus, M. / Schwarzenbacher, R. / Zhou, Q. / Sun, C. / Fesik, S.W. / Liddington, R.C. / Salvesen, G.S. |
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履歴 | 登録 | 2001年2月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2001年3月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2021年10月27日 | Group: Database references / Derived calculations カテゴリ: database_2 / pdbx_struct_conn_angle ...database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2023年8月9日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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