登録情報 | データベース: PDB / ID: 1fq3 |
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タイトル | CRYSTAL STRUCTURE OF HUMAN GRANZYME B |
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要素 | GRANZYME BグランザイムB |
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キーワード | HYDROLASE (加水分解酵素) / chymotrypsin-like serine proteinase |
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機能・相同性 | 機能・相同性情報
cytolytic granule lumen / グランザイムB / granzyme-mediated programmed cell death signaling pathway / cytolytic granule / Activation, myristolyation of BID and translocation to mitochondria / NOTCH2 intracellular domain regulates transcription / natural killer cell mediated cytotoxicity / pyroptotic inflammatory response / protein maturation / 免疫シナプス ...cytolytic granule lumen / グランザイムB / granzyme-mediated programmed cell death signaling pathway / cytolytic granule / Activation, myristolyation of BID and translocation to mitochondria / NOTCH2 intracellular domain regulates transcription / natural killer cell mediated cytotoxicity / pyroptotic inflammatory response / protein maturation / 免疫シナプス / Nuclear events stimulated by ALK signaling in cancer / Pyroptosis / serine-type peptidase activity / proteolysis involved in protein catabolic process / killing of cells of another organism / negative regulation of translation / serine-type endopeptidase activity / intracellular membrane-bounded organelle / apoptotic process / extracellular region / 生体膜 / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / Trypsin-like serine proteases ...Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Βバレル / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 3.1 Å |
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データ登録者 | Estebanez-Perpina, E. / Fuentes-Prior, P. / Belorgey, D. / Rubin, H. / Bode, W. |
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引用 | ジャーナル: Biol.Chem. / 年: 2000 タイトル: Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. 著者: Estebanez-Perpina, E. / Fuentes-Prior, P. / Belorgey, D. / Braun, M. / Kiefersauer, R. / Maskos, K. / Huber, R. / Rubin, H. / Bode, W. |
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履歴 | 登録 | 2000年9月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2001年1月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Non-polymer description / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues / pdbx_validate_chiral / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2024年4月3日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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