Entry Database : PDB / ID : 1.0E+88 Structure visualization Downloads & linksTitle Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding domain of human fibronectin ComponentsFIBRONECTIN Details Keywords CELL ADHESION / EXTRACELLULAR MATRIX GLYCOPROTEINFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of monocyte activation / calcium-independent cell-matrix adhesion / negative regulation of transforming growth factor beta production / Fibronectin matrix formation / Extracellular matrix organization / positive regulation of substrate-dependent cell migration, cell attachment to substrate / neural crest cell migration involved in autonomic nervous system development / peptidase activator activity / fibrinogen complex / peptide cross-linking ... negative regulation of monocyte activation / calcium-independent cell-matrix adhesion / negative regulation of transforming growth factor beta production / Fibronectin matrix formation / Extracellular matrix organization / positive regulation of substrate-dependent cell migration, cell attachment to substrate / neural crest cell migration involved in autonomic nervous system development / peptidase activator activity / fibrinogen complex / peptide cross-linking / integrin activation / ALK mutants bind TKIs / cell-substrate junction assembly / biological process involved in interaction with symbiont / Molecules associated with elastic fibres / proteoglycan binding / extracellular matrix structural constituent / MET activates PTK2 signaling / Syndecan interactions / p130Cas linkage to MAPK signaling for integrins / endodermal cell differentiation / GRB2:SOS provides linkage to MAPK signaling for Integrins / Non-integrin membrane-ECM interactions / basement membrane / endoplasmic reticulum-Golgi intermediate compartment / ECM proteoglycans / positive regulation of axon extension / Integrin cell surface interactions / collagen binding / Degradation of the extracellular matrix / Integrin signaling / substrate adhesion-dependent cell spreading / cell-matrix adhesion / extracellular matrix / regulation of ERK1 and ERK2 cascade / platelet alpha granule lumen / acute-phase response / integrin-mediated signaling pathway / Cell surface interactions at the vascular wall / Post-translational protein phosphorylation / regulation of protein phosphorylation / Signaling by high-kinase activity BRAF mutants / wound healing / MAP2K and MAPK activation / Signaling by ALK fusions and activated point mutants / response to wounding / GPER1 signaling / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of fibroblast proliferation / Signaling by BRAF and RAF1 fusions / integrin binding / Platelet degranulation / heparin binding / nervous system development / heart development / regulation of cell shape / Interleukin-4 and Interleukin-13 signaling / angiogenesis / collagen-containing extracellular matrix / protease binding / blood microparticle / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell adhesion / apical plasma membrane / endoplasmic reticulum lumen / signaling receptor binding / positive regulation of cell population proliferation / positive regulation of gene expression / extracellular space / extracellular exosome / extracellular region / identical protein binding / plasma membrane Similarity search - Function Fibronectin, type II, collagen-binding / Fibronectin type I domain / Fibronectin, type I / Fibronectin type-I domain signature. / Fibronectin type-I domain profile. / Fibronectin type 1 domain / Seminal Fluid Protein PDC-109 (Domain B) / Complement Module, domain 1 / Complement Module; domain 1 / Fibronectin type II domain ... Fibronectin, type II, collagen-binding / Fibronectin type I domain / Fibronectin, type I / Fibronectin type-I domain signature. / Fibronectin type-I domain profile. / Fibronectin type 1 domain / Seminal Fluid Protein PDC-109 (Domain B) / Complement Module, domain 1 / Complement Module; domain 1 / Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Kringle-like fold / EGF-like domain signature 1. / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Ribbon / Immunoglobulin-like fold / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method SOLUTION NMR / AB INITIO SIMULATED ANNEALING DetailsAuthors Pickford, A.R. / Smith, S.P. / Staunton, D. / Boyd, J. / Campbell, I.D. CitationJournal : Embo J. / Year : 2001Title : The Hairpin Structure of the (6)F1(1)F2(2)F2 Fragment from Human Fibronectin Enhances Gelatin BindingAuthors : Pickford, A.R. / Smith, S.P. / Staunton, D. / Boyd, J. / Campbell, I.D. History Deposition Sep 18, 2000 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 9, 2000 Provider : repository / Type : Initial releaseRevision 1.1 Oct 19, 2011 Group : Non-polymer description / Other ... Non-polymer description / Other / Structure summary / Version format compliance Revision 1.2 Nov 28, 2012 Group : Database references / Derived calculationsRevision 1.3 Feb 14, 2018 Group : Data collection / Database references / Source and taxonomyCategory : citation / entity_src_gen / pdbx_nmr_spectrometerItem : _citation.page_last / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id ... _citation.page_last / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _pdbx_nmr_spectrometer.manufacturer / _pdbx_nmr_spectrometer.type Revision 1.4 Jul 29, 2020 Group : Advisory / Data collection ... Advisory / Data collection / Derived calculations / Other / Structure summary Category : chem_comp / database_PDB_caveat ... chem_comp / database_PDB_caveat / entity / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_nonpoly / pdbx_nmr_software / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_database_status.status_code_mr / _pdbx_entity_nonpoly.name / _pdbx_nmr_software.name / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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