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Open data
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Basic information
Entry | Database: PDB / ID: 1au1 | ||||||||||||
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Title | HUMAN INTERFERON-BETA CRYSTAL STRUCTURE | ||||||||||||
![]() | INTERFERON-BETA | ||||||||||||
![]() | ![]() ![]() ![]() | ||||||||||||
Function / homology | ![]() regulation of MHC class I biosynthetic process / B cell activation involved in immune response / ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||||||||
Biological species | ![]() ![]() | ||||||||||||
Method | ![]() ![]() | ||||||||||||
![]() | Karpusas, M. / Nolte, M. / Lipscomb, W. | ||||||||||||
![]() | ![]() Title: The crystal structure of human interferon beta at 2.2-A resolution. Authors: Karpusas, M. / Nolte, M. / Benton, C.B. / Meier, W. / Lipscomb, W.N. / Goelz, S. | ||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 98.9 KB | Display | ![]() |
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PDB format | ![]() | 80.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 20054.080 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() #2: Polysaccharide | beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-3)-beta-D- ...beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-[alpha-D-quinovopyranose-(1-6)]beta-D-glucopyranose | ![]() Source method: isolated from a genetically manipulated source #3: Polysaccharide | alpha-D-quinovopyranose-(1-6)-beta-D-glucopyranose | ![]() Source method: isolated from a genetically manipulated source #4: Chemical | ChemComp-ZN / | #5: Water | ChemComp-HOH / | ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 4.83 Å3/Da / Density % sol: 55.43 % | ||||||||||||||||||||||||||||||
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Crystal grow![]() | pH: 7.5 / Details: pH 7.5 | ||||||||||||||||||||||||||||||
Crystal grow | *PLUS pH: 5 / Method: vapor diffusion, hanging dropDetails: drop solution was mixed with an equal volume of reservoir solution | ||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 108 K |
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Diffraction source | Source: ![]() |
Detector | Type: RIGAKU / Detector: IMAGE PLATE / Date: Jan 10, 1996 / Details: MIRRORS |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.2→30 Å / Num. obs: 18405 / % possible obs: 83.1 % / Observed criterion σ(I): 2 / Rmerge(I) obs: 0.0766 |
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Processing
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Refinement | Method to determine structure![]() ![]() Details: RESIDUES 28 - 30 OF MOLECULE B HAVE NOT BEEN MODELED DUE TO WEAK ELECTRON DENSITY.
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Refinement step | Cycle: LAST / Resolution: 2.2→30 Å
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Refine LS restraints |
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Software | *PLUS Name: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS |