RIBONUCLEOTIDE REDUCTASE / PEPTIDE INHIBITORS / TRANSFERRED NOESY / RESTRAINED MOLECULAR DYNAMICS / NONSTANDARD TYPE I TURN
Function / homology
Function and homology information
deoxyribonucleotide metabolic process / Interconversion of nucleotide di- and triphosphates / ribonucleoside diphosphate metabolic process / 2'-deoxyribonucleotide biosynthetic process / ribonucleoside-diphosphate reductase complex / ribonucleoside-diphosphate reductase / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor / deoxyribonucleotide biosynthetic process / protein heterotetramerization / blastocyst development ...deoxyribonucleotide metabolic process / Interconversion of nucleotide di- and triphosphates / ribonucleoside diphosphate metabolic process / 2'-deoxyribonucleotide biosynthetic process / ribonucleoside-diphosphate reductase complex / ribonucleoside-diphosphate reductase / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor / deoxyribonucleotide biosynthetic process / protein heterotetramerization / blastocyst development / positive regulation of G1/S transition of mitotic cell cycle / ferric iron binding / nuclear envelope / protein homodimerization activity / identical protein binding / cytosol Similarity search - Function
Ribonucleotide reductase small subunit, acitve site / Ribonucleotide reductase small subunit signature. / Ribonucleotide reductase small subunit / Ribonucleotide reductase small subunit family / Ribonucleotide reductase, small chain / Ribonucleotide reductase-like / Ferritin-like superfamily Similarity search - Domain/homology
Mass: 853.916 Da / Num. of mol.: 1 / Fragment: C-TERMINAL RESIDUES AC-FTLDADF OF SMALL SUBUNIT Source method: isolated from a genetically manipulated source Details: SYNTHESIZED USING FMOC CHEMISTRY References: UniProt: P11157, ribonucleoside-diphosphate reductase
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
TRNOESY
1
2
1
NOESY
1
3
1
TOCSY
1
4
1
ROESY
-
Sample preparation
Sample conditions
pH: 7.0 / Temperature: 287 K
Crystal grow
*PLUS
Method: other / Details: NMR
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NMR measurement
NMR spectrometer
Type
Manufacturer
Model
Field strength (MHz)
Spectrometer-ID
Bruker AMX500
Bruker
AMX500
500
1
Bruker DMX500
Bruker
DMX500
600
2
Bruker AMX600
Bruker
AMX600
600
3
-
Processing
Software
Name
Version
Classification
X-PLOR
3
modelbuilding
X-PLOR
3
refinement
X-PLOR
3
phasing
NMR software
Name
Version
Developer
Classification
X-PLOR
3
BRUNGER
refinement
XPLOR
structuresolution
Refinement
Method: SIMULATED ANNEALING IMPLEMENTED WITH RESTRAINED MOLECULAR DYNAMICS Software ordinal: 1 Details: SEE JRNL REFERENCE FOR REFINEMENT DETAILS. THE AUTHORS DID NOT MAKE OR ATTEMPT TO MAKE STEREOSPECIFIC ASSIGNMENTS.
NMR ensemble
Conformer selection criteria: LEAST RESTRAINT VIOLATIONS, POTENTIAL ENERGY Conformers calculated total number: 299 / Conformers submitted total number: 26
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