登録情報 | データベース: EMDB / ID: EMD-36727 |
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タイトル | Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (1-up state) |
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マップデータ | |
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試料 | - 複合体: SARS-CoV-2 XBB1.5 spike glycoprotein with ACE2
- タンパク質・ペプチド: Spike glycoprotein
- タンパク質・ペプチド: Processed angiotensin-converting enzyme 2
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | spike protein / glycoprotein / VIRUS / VIRAL PROTEIN-PROTEIN BINDING complex |
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機能・相同性 | 機能・相同性情報
positive regulation of amino acid transport / angiotensin-converting enzyme 2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of cardiac conduction / regulation of vasoconstriction ...positive regulation of amino acid transport / angiotensin-converting enzyme 2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of cardiac conduction / regulation of vasoconstriction / peptidyl-dipeptidase activity / maternal process involved in female pregnancy / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / negative regulation of signaling receptor activity / carboxypeptidase activity / Attachment and Entry / positive regulation of cardiac muscle contraction / viral life cycle / regulation of cytokine production / blood vessel diameter maintenance / negative regulation of smooth muscle cell proliferation / brush border membrane / regulation of transmembrane transporter activity / cilium / negative regulation of ERK1 and ERK2 cascade / metallopeptidase activity / positive regulation of reactive oxygen species metabolic process / endocytic vesicle membrane / virus receptor activity / regulation of cell population proliferation / regulation of inflammatory response / endopeptidase activity / Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Potential therapeutics for SARS / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / membrane fusion / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / symbiont-mediated suppression of host innate immune response / symbiont entry into host cell / membrane raft / apical plasma membrane / endoplasmic reticulum lumen / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / cell surface / extracellular space / extracellular exosome / zinc ion binding / extracellular region / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Collectrin domain / Renal amino acid transporter / Collectrin-like domain profile. / Peptidase M2, peptidyl-dipeptidase A / Angiotensin-converting enzyme / Peptidase family M2 domain profile. / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Coronavirus spike glycoprotein S1, C-terminal ...Collectrin domain / Renal amino acid transporter / Collectrin-like domain profile. / Peptidase M2, peptidyl-dipeptidase A / Angiotensin-converting enzyme / Peptidase family M2 domain profile. / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Spike glycoprotein, betacoronavirus / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2類似検索 - ドメイン・相同性 Spike glycoprotein / Angiotensin-converting enzyme 2類似検索 - 構成要素 |
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生物種 | Severe acute respiratory syndrome coronavirus 2 (ウイルス) / Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.04 Å |
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データ登録者 | Yajima H / Anraku Y / Kita S / Kimura K / Sasaki J / Sasaki-Tabata K / Maenaka K / Hashiguchi T |
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資金援助 | 日本, 5件 Organization | Grant number | 国 |
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Japan Agency for Medical Research and Development (AMED) | JP21am0101093 | 日本 | Japan Agency for Medical Research and Development (AMED) | JP22ama121037 | 日本 | Japan Science and Technology | JPMJCR20H8 | 日本 | Japan Society for the Promotion of Science (JSPS) | 20H05773 | 日本 | Japan Society for the Promotion of Science (JSPS) | JP20H05873 | 日本 |
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引用 | ジャーナル: To Be Published タイトル: Virological characteristics of the SARS-CoV-2 XBB.1.5 variant 著者: Tamura T / Ito J / Uriu K / Zahradnik J / Kida I / Anraku Y / Nasser H / Shofa M / Oda Y / Lytras S / Nao N / Itakura Y / Deguchi S / Suzuki R / Wang L / Begum MM / Kita S / Yajima H / Sasaki ...著者: Tamura T / Ito J / Uriu K / Zahradnik J / Kida I / Anraku Y / Nasser H / Shofa M / Oda Y / Lytras S / Nao N / Itakura Y / Deguchi S / Suzuki R / Wang L / Begum MM / Kita S / Yajima H / Sasaki J / Sasaki-Tabata K / Shimizu R / Tsuda M / Kosugi Y / Fujita S / Pan L / Sauter D / Yoshimatsu K / Suzuki S / Asakura H / Nagashima M / Sadamasu K / Yoshimura K / Yamamoto Y / Nagamoto T / Schreiber G / Maenaka K / Hashiguchi T / Ikeda T / Fukuhara T / Saito A / Tanaka S / Matsuno K / Takayama K / Sato K |
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履歴 | 登録 | 2023年7月3日 | - |
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ヘッダ(付随情報) 公開 | 2024年1月3日 | - |
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マップ公開 | 2024年1月3日 | - |
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更新 | 2024年1月3日 | - |
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現状 | 2024年1月3日 | 処理サイト: PDBj / 状態: 公開 |
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