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TitleStructure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Journal, issue, pagesCell, Vol. 186, Issue 10, Page 2219-2237.e29, Year 2023
Publish dateMay 11, 2023
AuthorsMichael D Healy / Kerrie E McNally / Rebeka Butkovič / Molly Chilton / Kohji Kato / Joanna Sacharz / Calum McConville / Edmund R R Moody / Shrestha Shaw / Vicente J Planelles-Herrero / Sathish K N Yadav / Jennifer Ross / Ufuk Borucu / Catherine S Palmer / Kai-En Chen / Tristan I Croll / Ryan J Hall / Nikeisha J Caruana / Rajesh Ghai / Thi H D Nguyen / Kate J Heesom / Shinji Saitoh / Imre Berger / Christiane Schaffitzel / Tom A Williams / David A Stroud / Emmanuel Derivery / Brett M Collins / Peter J Cullen /
PubMed AbstractThe Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, ...The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93. Combining X-ray crystallography, electron cryomicroscopy, and in silico predictions, we have assembled a complete structural model of Commander. Retriever is distantly related to the endosomal Retromer complex but has unique features preventing the shared VPS29 subunit from interacting with Retromer-associated factors. The COMMD proteins form a distinctive hetero-decameric ring stabilized by extensive interactions with CCDC22 and CCDC93. These adopt a coiled-coil structure that connects the CCC and Retriever assemblies and recruits a 16th subunit, DENND10, to form the complete Commander complex. The structure allows mapping of disease-causing mutations and reveals the molecular features required for the function of this evolutionarily conserved trafficking machinery.
External linksCell / PubMed:37172566 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution1.35 - 3.53 Å
Structure data

28825

8f2r

EMDB-28825, PDB-8f2r:
Human CCC complex
Method: EM (single particle) / Resolution: 3.12 Å

28827

8f2u

EMDB-28827, PDB-8f2u:
Human CCC complex
Method: EM (single particle) / Resolution: 3.53 Å

PDB-8esd:
Crystal structure of COMMD7-COMMD9-COMMD5-COMMD10 tetramer
Method: X-RAY DIFFRACTION / Resolution: 3.33 Å

PDB-8ese:
Crystal structure of human Vps29 bound to a peptide from Vps35L
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • homo sapiens (human)
KeywordsENDOCYTOSIS / Complex / Commander / Retriever / Commd5 / Commd7 / Commd9 / Commd10 / Commd / Vps29 / Vps35L / endosomal sorting / CCC complex

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