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TitleIdentical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy.
Journal, issue, pagesActa Neuropathol Commun, Vol. 11, Issue 1, Page 74, Year 2023
Publish dateMay 5, 2023
AuthorsChao Qi / Masato Hasegawa / Masaki Takao / Motoko Sakai / Mayasuki Sasaki / Masashi Mizutani / Akio Akagi / Yasushi Iwasaki / Hiroaki Miyahara / Mari Yoshida / Sjors H W Scheres / Michel Goedert /
PubMed AbstractSubacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), ...Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), which happens after repetitive head impacts or exposure to blast waves, following a symptom-free period. As in CTE, the neurofibrillary changes of SSPE are concentrated in superficial cortical layers. Here we used electron cryo-microscopy (cryo-EM) of tau filaments from two cases of SSPE to show that the tau folds of SSPE and CTE are identical. Two types of filaments were each made of two identical protofilaments with an extra density in the β-helix region. Like in CTE, the vast majority of tau filaments were Type I, with a minority of Type II filaments. These findings suggest that the CTE tau fold can be caused by different environmental insults, which may be linked by inflammatory changes.
External linksActa Neuropathol Commun / PubMed:37143123 / PubMed Central
MethodsEM (helical sym.)
Resolution2.3 - 3.7 Å
Structure data

16532

8caq

EMDB-16532, PDB-8caq:
Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis
Method: EM (helical sym.) / Resolution: 2.3 Å

16535

8cax

EMDB-16535, PDB-8cax:
Structure of Tau filaments Type II from Subacute Sclerosing Panencephalitis
Method: EM (helical sym.) / Resolution: 3.7 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Tau filament / SSPE / Neurodegenerative disease

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