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TitleCryo-EM structure of the mature dengue virus at 3.5-Å resolution.
Journal, issue, pagesNat Struct Mol Biol, Vol. 20, Issue 1, Page 105-110, Year 2013
Publish dateDec 16, 2012
AuthorsXiaokang Zhang / Peng Ge / Xuekui Yu / Jennifer M Brannan / Guoqiang Bi / Qinfen Zhang / Stan Schein / Z Hong Zhou /
PubMed AbstractRegulated by pH, membrane-anchored proteins E and M function during dengue virus maturation and membrane fusion. Our atomic model of the whole virion from cryo-electron microscopy at 3.5-Å ...Regulated by pH, membrane-anchored proteins E and M function during dengue virus maturation and membrane fusion. Our atomic model of the whole virion from cryo-electron microscopy at 3.5-Å resolution reveals that in the mature virus at neutral extracellular pH, the N-terminal 20-amino-acid segment of M (involving three pH-sensing histidines) latches and thereby prevents spring-loaded E fusion protein from prematurely exposing its fusion peptide. This M latch is fastened at an earlier stage, during maturation at acidic pH in the trans-Golgi network. At a later stage, to initiate infection in response to acidic pH in the late endosome, M releases the latch and exposes the fusion peptide. Thus, M serves as a multistep chaperone of E to control the conformational changes accompanying maturation and infection. These pH-sensitive interactions could serve as targets for drug discovery.
External linksNat Struct Mol Biol / PubMed:23241927 / PubMed Central
MethodsEM (single particle)
Resolution3.6 Å
Structure data

5499

3j2p

EMDB-5499: CryoEM structure of Dengue virus, partial map
PDB-3j2p: CryoEM structure of Dengue virus envelope protein heterotetramer
Method: EM (single particle) / Resolution: 3.6 Å

5520

3j27

EMDB-5520: CryoEM structure of Dengue virus, full map
PDB-3j27: CryoEM structure of Dengue virus
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • dengue virus 2
KeywordsVIRUS / flavivirus / fusion protein / protein complex / membrane / chaperone / VIRAL PROTEIN

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