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| Title | Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection. |
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| Journal, issue, pages | Immunity, Vol. 56, Issue 11, Page 2635-22649.e6, Year 2023 |
| Publish date | Nov 14, 2023 |
 Authors | Ruoke Wang / Yang Han / Rui Zhang / Jiayi Zhu / Xuanyu Nan / Yaping Liu / Ziqing Yang / Bini Zhou / Jinfang Yu / Zichun Lin / Jinqian Li / Peng Chen / Yangjunqi Wang / Yujie Li / Dongsheng Liu / Xuanling Shi / Xinquan Wang / Qi Zhang / Yuhe R Yang / Taisheng Li / Linqi Zhang /  |
| PubMed Abstract | The 2003 severe acute respiratory syndrome coronavirus (SARS-CoV-1) causes more severe disease than SARS-CoV-2, which is responsible for COVID-19. However, our understanding of antibody response to ...The 2003 severe acute respiratory syndrome coronavirus (SARS-CoV-1) causes more severe disease than SARS-CoV-2, which is responsible for COVID-19. However, our understanding of antibody response to SARS-CoV-1 infection remains incomplete. Herein, we studied the antibody responses in 25 SARS-CoV-1 convalescent patients. Plasma neutralization was higher and lasted longer in SARS-CoV-1 patients than in severe SARS-CoV-2 patients. Among 77 monoclonal antibodies (mAbs) isolated, 60 targeted the receptor-binding domain (RBD) and formed 7 groups (RBD-1 to RBD-7) based on their distinct binding and structural profiles. Notably, RBD-7 antibodies bound to a unique RBD region interfaced with the N-terminal domain of the neighboring protomer (NTD proximal) and were more prevalent in SARS-CoV-1 patients. Broadly neutralizing antibodies for SARS-CoV-1, SARS-CoV-2, and bat and pangolin coronaviruses were also identified. These results provide further insights into the antibody response to SARS-CoV-1 and inform the design of more effective strategies against diverse human and animal coronaviruses. |
 External links | Immunity / PubMed:37924813 |
| Methods | EM (single particle) |
| Resolution | 3.48 - 25.0 Å |
| Structure data |  EMDB-34503: Immune complex of W322-3A8 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34550: Immune complex of W322-3D10 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34553: Immune complex of W328-5B1 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34557: Immune complex of W322-3E12 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34558: Immune complex of W305-2A5 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34559: Immune complex of W313-6D11 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34560: Immune complex of W322-3B1 Fab binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34561: Immune complex of W322-3G5 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34562: Immune complex of W328-6F1 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34599: Immune complex of W305-2G7 IgG binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34600: Immune complex of W305-2A4 Fab binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34601: Immune complex of W328-6G6 Fab binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34604: Immune complex of W328-6H2 Fab binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34605: Immune complex of W322-3F4 Fab binding the RBD of SARS-CoV-1 2P spike protein  EMDB-34606: Immune complex of W322-3H7 Fab binding the RBD of SARS-CoV-1 2P spike protein  EMDB-36636: Cryo-EM structure of SARS-CoV-1 2P spike protein in complex with W328-6A1 IgG  EMDB-36647: Cryo-EM structure of SARS-CoV-1 2P spike protein in complex with W328-6E10 Fab  EMDB-36648: Cryo-EM structure of SARS-CoV-1 2P spike protein protomer in complex with W328-6E10 (local refine) |
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Homo sapiens (human)
