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TitleProtective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2.
Journal, issue, pagesCell, Vol. 185, Issue 13, Page 2265-2278.e14, Year 2022
Publish dateJun 23, 2022
AuthorsKun Xu / Ping Gao / Sheng Liu / Shuaiyao Lu / Wenwen Lei / Tianyi Zheng / Xueyuan Liu / Yufeng Xie / Zhennan Zhao / Shuxin Guo / Cong Tang / Yun Yang / Wenhai Yu / Junbin Wang / Yanan Zhou / Qing Huang / Chuanyu Liu / Yaling An / Rong Zhang / Yuxuan Han / Minrun Duan / Shaofeng Wang / Chenxi Yang / Changwei Wu / Xiaoya Liu / Guangbiao She / Yan Liu / Xin Zhao / Ke Xu / Jianxun Qi / Guizhen Wu / Xiaozhong Peng / Lianpan Dai / Peiyi Wang / George F Gao /
PubMed AbstractBreakthrough infections by SARS-CoV-2 variants become the global challenge for pandemic control. Previously, we developed the protein subunit vaccine ZF2001 based on the dimeric receptor-binding ...Breakthrough infections by SARS-CoV-2 variants become the global challenge for pandemic control. Previously, we developed the protein subunit vaccine ZF2001 based on the dimeric receptor-binding domain (RBD) of prototype SARS-CoV-2. Here, we developed a chimeric RBD-dimer vaccine approach to adapt SARS-CoV-2 variants. A prototype-Beta chimeric RBD-dimer was first designed to adapt the resistant Beta variant. Compared with its homotypic forms, the chimeric vaccine elicited broader sera neutralization of variants and conferred better protection in mice. The protection of the chimeric vaccine was further verified in macaques. This approach was generalized to develop Delta-Omicron chimeric RBD-dimer to adapt the currently prevalent variants. Again, the chimeric vaccine elicited broader sera neutralization of SARS-CoV-2 variants and conferred better protection against challenge by either Delta or Omicron SARS-CoV-2 in mice. The chimeric approach is applicable for rapid updating of immunogens, and our data supported the use of variant-adapted multivalent vaccine against circulating and emerging variants.
External linksCell / PubMed:35568034 / PubMed Central
MethodsEM (single particle)
Resolution11.5 Å
Structure data

EMDB-33225: Cryo-EM structure of SARS-CoV-2 prototype RBD-dimer bound to CB6 Fab
Method: EM (single particle) / Resolution: 11.5 Å

Source
  • Severe acute respiratory syndrome coronavirus 2

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