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TitleStructural evolution of glycan recognition by a family of potent HIV antibodies.
Journal, issue, pagesCell, Vol. 159, Issue 1, Page 69-79, Year 2014
Publish dateSep 25, 2014
AuthorsFernando Garces / Devin Sok / Leopold Kong / Ryan McBride / Helen J Kim / Karen F Saye-Francisco / Jean-Philippe Julien / Yuanzi Hua / Albert Cupo / John P Moore / James C Paulson / Andrew B Ward / Dennis R Burton / Ian A Wilson /
PubMed AbstractThe HIV envelope glycoprotein (Env) is densely covered with self-glycans that should help shield it from recognition by the human immune system. Here, we examine how a particularly potent family of ...The HIV envelope glycoprotein (Env) is densely covered with self-glycans that should help shield it from recognition by the human immune system. Here, we examine how a particularly potent family of broadly neutralizing antibodies (Abs) has evolved common and distinct structural features to counter the glycan shield and interact with both glycan and protein components of HIV Env. The inferred germline antibody already harbors potential binding pockets for a glycan and a short protein segment. Affinity maturation then leads to divergent evolutionary branches that either focus on a single glycan and protein segment (e.g., Ab PGT124) or engage multiple glycans (e.g., Abs PGT121-123). Furthermore, other surrounding glycans are avoided by selecting an appropriate initial antibody shape that prevents steric hindrance. Such molecular recognition lessons are important for engineering proteins that can recognize or accommodate glycans.
External linksCell / PubMed:25259921 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution2.4969 - 17.8 Å
Structure data

EMDB-2753:
PGT124 in complex with BG505 SOSIP.664 Env trimer
Method: EM (single particle) / Resolution: 17.8 Å

PDB-4r26:
Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody
Method: X-RAY DIFFRACTION / Resolution: 2.4969 Å

PDB-4r2g:
Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4
Method: X-RAY DIFFRACTION / Resolution: 3.283 Å

Chemicals

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-HOH:
WATER / Water

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-CL:
Unknown entry / Chloride

Source
  • homo sapiens (human)
  • nomascus leucogenys (northern white-cheeked gibbon)
  • human immunodeficiency virus type 1 group m subtype b
KeywordsIMMUNE SYSTEM / IGG Fold / Antibody / HIV-1 binding / Protein-Protein complex / IgG / Anti-HIV antibodies / gp120

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