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Structure paper

TitleStructural basis for Fc receptor recognition of immunoglobulin M.
Journal, issue, pagesNat Struct Mol Biol, Vol. 30, Issue 7, Page 1033-1039, Year 2023
Publish dateApr 24, 2023
AuthorsQu Chen / Rajesh P Menon / Laura Masino / Pavel Tolar / Peter B Rosenthal /
PubMed AbstractImmunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune ...Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of antibody production. FcμR is the immunoglobulin M (IgM) antibody isotype-specific Fc receptor involved in the survival and activation of B cells. Here we reveal eight binding sites for the human FcμR immunoglobulin domain on the IgM pentamer by cryogenic electron microscopy. One of the sites overlaps with the binding site for the polymeric immunoglobulin receptor (pIgR), but a different mode of FcμR binding explains its antibody isotype specificity. Variation in FcμR binding sites and their occupancy reflects the asymmetry of the IgM pentameric core and the versatility of FcμR binding. The complex explains engagement with polymeric serum IgM and the monomeric IgM B-cell receptor (BCR).
External linksNat Struct Mol Biol / PubMed:37095205 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.63 Å
Structure data

16150

8bpe

EMDB-16150, PDB-8bpe:
8:1 binding of FcMR on IgM pentameric core
Method: EM (single particle) / Resolution: 3.63 Å

16151

8bpf

EMDB-16151, PDB-8bpf:
FcMR binding at subunit Fcu1 of IgM pentamer
Method: EM (single particle) / Resolution: 3.5 Å

16152

8bpg

EMDB-16152, PDB-8bpg:
FcMR binding at subunit Fcu3 of IgM pentamer
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • homo sapiens (human)
  • human (human)
KeywordsIMMUNE SYSTEM / IgM Fc receptor

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