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-Structure paper
タイトル | Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. |
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ジャーナル・号・ページ | Adv Sci (Weinh), Vol. 9, Issue 15, Page e2200063, Year 2022 |
掲載日 | 2022年3月23日 |
著者 | Nan Gao / Yanxin Gai / Lina Meng / Chu Wang / Wei Wang / Xiaojun Li / Tiejun Gu / Mark K Louder / Nicole A Doria-Rose / Kevin Wiehe / Alexandra F Nazzari / Adam S Olia / Jason Gorman / Reda Rawi / Wenmin Wu / Clayton Smith / Htet Khant / Natalia de Val / Bin Yu / Junhong Luo / Haitao Niu / Yaroslav Tsybovsky / Huaxin Liao / Thomas B Kepler / Peter D Kwong / John R Mascola / Chuan Qin / Tongqing Zhou / Xianghui Yu / Feng Gao / |
PubMed 要旨 | Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV-1 can be highly informative for HIV-1 vaccine development. A lineage of J038 bnAbs is now obtained from a long- ...Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV-1 can be highly informative for HIV-1 vaccine development. A lineage of J038 bnAbs is now obtained from a long-term SHIV-infected macaque. J038 neutralizes 54% of global circulating HIV-1 strains. Its binding induces a unique "up" conformation for one of the V2 loops in the trimeric envelope glycoprotein and is heavily dependent on glycan, which provides nearly half of the binding surface. Their unmutated common ancestor neutralizes the autologous virus. Continuous maturation enhances neutralization potency and breadth of J038 lineage antibodies via expanding antibody-Env contact areas surrounding the core region contacted by germline-encoded residues. Developmental details and recognition features of J038 lineage antibodies revealed here provide a new pathway for elicitation and maturation of V2-targeting bnAbs. |
リンク | Adv Sci (Weinh) / PubMed:35319830 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.4 - 4.2 Å |
構造データ | EMDB-24071, PDB-7mxd: EMDB-24128, PDB-7n28: |
化合物 | ChemComp-NAG: ChemComp-PO4: ChemComp-MAN: |
由来 |
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キーワード | IMMUNE SYSTEM/VIRAL PROTEIN (免疫系) / HIV-1 / SIV-1 / V2-apex / envelope glycoprotein / neutralizing antibody (中和抗体) / glycan-dependent / IMMUNE SYSTEM-VIRAL PROTEIN complex (免疫系) |