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TitleAllosteric Determinants in High Temperature Requirement A Enzymes Are Conserved and Regulate the Population of Active Conformations.
Journal, issue, pagesAcs Chem. Biol., Vol. 18, Page 1487-1499, Year 2023
Publish dateNov 15, 2021 (structure data deposition date)
AuthorsGupta, A.K. / Singh, K. / Patidar, Y. / Sharma, R. / Sardesai, A.A. / Reddy, G. / Gopal, B.
External linksAcs Chem. Biol. / PubMed:37319329
MethodsX-ray diffraction
Resolution1.9 - 2.9 Å
Structure data

PDB-7vyz:
Structure of the M. tuberculosis HtrA S367A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.401 Å

PDB-7vz0:
Structure of the M. tuberculosis HtrA S407A mutant
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7w21:
Structure of the M. tuberculosis HtrA N269A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-7w22:
Structure of the M. tuberculosis HtrA K436A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-7w23:
Structure of the M. tuberculosis HtrA S363A mutant
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7w24:
Structure of the M. tuberculosis HtrA N383A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-7w25:
Structure of the M. tuberculosis HtrA S413A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-7w4r:
Structure of the M. tuberculosis HtrA N269A mutant at room-temperature
Method: X-RAY DIFFRACTION / Resolution: 2.701 Å

PDB-7w4s:
Structure of the M. tuberculosis HtrA S363A mutant at room-temperature
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7w4t:
Structure of the M. tuberculosis HtrA S367A mutant at room-temperature
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7w4u:
Structure of the M. tuberculosis HtrA S407A mutant at room-temperature
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-7w4v:
Structure of the M. tuberculosis HtrA S413A mutant at room temperature
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7w4w:
Structure of the M. tuberculosis HtrA K436A mutant at room-temperature
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • mycobacterium tuberculosis (strain atcc 25618 / h37rv) (bacteria)
  • mycobacterium tuberculosis h37rv (bacteria)
KeywordsHYDROLASE / HtrA family of serine protease / chymotrypsin like / Periplasm / Protein quality control and signal transduction. / chymotrypsin-like / Protein quality control / signal transduction and room temperature data. / signal transduction and room-temperature data. / signal transduction and room-temperature data

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