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Title | Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation. |
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Journal, issue, pages | Sci Adv, Vol. 8, Page eabm1759-eabm1759, Year 2022 |
Publish date | May 3, 2020 (structure data deposition date) |
Authors | Kissel, T. / Ge, C. / Hafkenscheid, L. / Kwekkeboom, J.C. / Slot, L.M. / Cavallari, M. / He, Y. / van Schie, K.A. / Vergroesen, R.D. / Kampstra, A.S.B. ...Kissel, T. / Ge, C. / Hafkenscheid, L. / Kwekkeboom, J.C. / Slot, L.M. / Cavallari, M. / He, Y. / van Schie, K.A. / Vergroesen, R.D. / Kampstra, A.S.B. / Reijm, S. / Stoeken-Rijsbergen, G. / Koeleman, C. / Voortman, L.M. / Heitman, L.H. / Xu, B. / Pruijn, G.J.M. / Wuhrer, M. / Rispens, T. / Huizinga, T.W.J. / Scherer, H.U. / Reth, M. / Holmdahl, R. / Toes, R.E.M. |
External links | Sci Adv / PubMed:35138894 |
Methods | X-ray diffraction |
Resolution | 2 - 2.85 Å |
Structure data | PDB-6yxk: PDB-6yxl: PDB-6yxm: |
Chemicals | ChemComp-NAG: ChemComp-HOH: ChemComp-GOL: ChemComp-SO4: ChemComp-ZN: |
Source |
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Keywords | IMMUNE SYSTEM / anti-citrullinated protein antibody Fab fragment / citrullinated vimentin / anti-citrullinated protein antibody / collagen type II |