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Structure paper

TitleStructurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.
Journal, issue, pagesPlos Pathog., Vol. 17, Page e1009543-e1009543, Year 2021
Publish dateJan 16, 2020 (structure data deposition date)
AuthorsAljedani, S.S. / Liban, T.J. / Tran, K. / Phad, G. / Singh, S. / Dubrovskaya, V. / Pushparaj, P. / Martinez-Murillo, P. / Rodarte, J. / Mileant, A. ...Aljedani, S.S. / Liban, T.J. / Tran, K. / Phad, G. / Singh, S. / Dubrovskaya, V. / Pushparaj, P. / Martinez-Murillo, P. / Rodarte, J. / Mileant, A. / Mangala Prasad, V. / Kinzelman, R. / O'Dell, S. / Mascola, J.R. / Lee, K.K. / Karlsson Hedestam, G.B. / Wyatt, R.T. / Pancera, M.
External linksPlos Pathog. / PubMed:34559844
MethodsX-ray diffraction
Resolution1.904 - 2.87 Å
Structure data

PDB-6vjn:
Structure of NHP D11A.B5Fab in complex with 16055 V2b peptide
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-6was:
Structure of D19.PA8 Fab in complex with 1FD6 16055 V1V2 scaffold
Method: X-RAY DIFFRACTION / Resolution: 1.904 Å

PDB-6wit:
Crystal structure of NHP D15.SD7 Fab in complex with 16055 V1V2 1FD6 scaffold
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-6xlz:
Structure of NHP D11A.F2 Fab in complex with 16055 V2b peptide
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6xsn:
Crystal structure of NHP VD20.5A4 Fab in complex with 16055 V1V2 1FD6 scaffold
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-SO4:
SULFATE ION / Sulfate

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-SCN:
THIOCYANATE ION / Thiocyanate

ChemComp-EDO:
1,2-ETHANEDIOL / Ethylene glycol

Source
  • homo sapiens (human)
  • macaca mulatta (Rhesus monkey)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / Fragment binding antigen and peptide complex / ANTIVIRAL PROTEIN/IMMUNE SYSTEM / Fab / HIV / V1V2 / Complex / Antibody / Scaffold / ANTIVIRAL PROTEIN-IMMUNE SYSTEM complex / VD20.5A4 Fab / NHPs / 16055 V1V2 / 1FD6 scaffold

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