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TitleA common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Journal, issue, pagesActa Neuropathol Commun, Vol. 6, Page 43-43, Year 2018
Publish dateMay 9, 2018 (structure data deposition date)
AuthorsApetri, A. / Crespo, R. / Juraszek, J. / Pascual, G. / Janson, R. / Zhu, X. / Zhang, H. / Keogh, E. / Holland, T. / Wadia, J. ...Apetri, A. / Crespo, R. / Juraszek, J. / Pascual, G. / Janson, R. / Zhu, X. / Zhang, H. / Keogh, E. / Holland, T. / Wadia, J. / Verveen, H. / Siregar, B. / Mrosek, M. / Taggenbrock, R. / Ameijde, J. / Inganas, H. / van Winsen, M. / Koldijk, M.H. / Zuijdgeest, D. / Borgers, M. / Dockx, K. / Stoop, E.J.M. / Yu, W. / Brinkman-van der Linden, E.C. / Ummenthum, K. / van Kolen, K. / Mercken, M. / Steinbacher, S. / de Marco, D. / Hoozemans, J.J. / Wilson, I.A. / Koudstaal, W. / Goudsmit, J.
External linksActa Neuropathol Commun / PubMed:29855358
MethodsX-ray diffraction
Resolution1.9 - 2.95 Å
Structure data

PDB-5zv3:
Crystal structure of human anti-tau antibody CBTAU-28.1 in complex with its tau peptide
Method: X-RAY DIFFRACTION / Resolution: 2.093 Å

PDB-6dcv:
Crystal structure of human anti-tau antibody CBTAU-27.1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6dcw:
Crystal structure of human anti-tau antibody CBTAU-27.1 Fab in complex with a human tau peptide
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-6gk7:
Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318)
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-6gk8:
Crystal structure of anti-tau antibody dmCBTAU-28.1, double mutant (S32R, E35K) of CBTAU-28.1, in complex with Tau peptide A7731 (residues 52-71)
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-HOH:
WATER / Water

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-CL:
Unknown entry / Chloride

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody / tau protein / peptide antigen / Tau / Fab / naturally occurring human antibody / common motif / COMPLEX

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