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Structure paper

TitleStructure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology.
Journal, issue, pagesMol Cell, Vol. 63, Issue 3, Page 445-456, Year 2016
Publish dateAug 4, 2016
AuthorsAlexander Hahn / Kristian Parey / Maike Bublitz / Deryck J Mills / Volker Zickermann / Janet Vonck / Werner Kühlbrandt / Thomas Meier /
PubMed AbstractWe determined the structure of a complete, dimeric F1Fo-ATP synthase from yeast Yarrowia lipolytica mitochondria by a combination of cryo-EM and X-ray crystallography. The final structure resolves 58 ...We determined the structure of a complete, dimeric F1Fo-ATP synthase from yeast Yarrowia lipolytica mitochondria by a combination of cryo-EM and X-ray crystallography. The final structure resolves 58 of the 60 dimer subunits. Horizontal helices of subunit a in Fo wrap around the c-ring rotor, and a total of six vertical helices assigned to subunits a, b, f, i, and 8 span the membrane. Subunit 8 (A6L in human) is an evolutionary derivative of the bacterial b subunit. On the lumenal membrane surface, subunit f establishes direct contact between the two monomers. Comparison with a cryo-EM map of the F1Fo monomer identifies subunits e and g at the lateral dimer interface. They do not form dimer contacts but enable dimer formation by inducing a strong membrane curvature of ∼100°. Our structure explains the structural basis of cristae formation in mitochondria, a landmark signature of eukaryotic cell morphology.
External linksMol Cell / PubMed:27373333 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution3.5 - 9.6 Å
Structure data

EMDB-8151:
F1Fo ATP synthase dimer from Yarrowia lipolytica
Method: EM (single particle) / Resolution: 7.7 Å

EMDB-8152:
F1Fo ATP synthase dimer from Yarrowia lipolytica
Method: EM (single particle) / Resolution: 7.2 Å

EMDB-8153:
Masked monomer of ATP synthase dimer from Yarrowia lipolytica, subclass 1
Method: EM (single particle) / Resolution: 9.6 Å

EMDB-8154:
Masked monomer of ATP synthase dimer from Yarrowia lipolytica, subclass 2
Method: EM (single particle) / Resolution: 7.5 Å

EMDB-8155:
Masked monomer of ATP synthase dimer from Yarrowia lipolytica, subclass 3
Method: EM (single particle) / Resolution: 7.8 Å

PDB-5fl7:
Structure of the F1c10 complex from Yarrowia lipolytica ATP synthase
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

ChemComp-MG:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM / Adenosine diphosphate

ChemComp-HOH:
WATER / Water

Source
  • yarrowia lipolytica (yeast)
KeywordsHYDROLASE / ATP SYNTHASE FAMILY / NUCLEOTIDE BINDING / PROTON TRANSPORTING / ROTATIONAL MECHANISM / ATP BIOSYNTHETIC PROCESS / ATP SYNTHESIS/HYDROLYSIS

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